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Endocrine Abstracts (2014) 35 P1076 | DOI: 10.1530/endoabs.35.P1076

Armed Forces Hospital, Lisbon, Portugal.

The thyroid pathology is an area of special interest in our department. Hyperthyroidism represents 3.4% of the 8144 patients followed.

The aim of this study is to characterize the therapeutic approach in patients with Grave’s disease (GD) and toxic nodular disease (TND).

Retrospective study of 217 patients diagnosed with GD and TND, evaluated according parameters of therapeutic option, efficacy, relapse rate and associated complications at 6 months and 1 year. Variables were analyzed by methods of descriptive statistics: frequency and contingency tables for categorical variables and mean, s.d., minimum and maximum for continuous variables. From 217 patients, 138 were included in the study (91 GD and 47 TND). In TND 68% were female, aged 59.5±13.2 years. GD 75% were female, aged 42.69±15 years.

In both diseases the decision for surgical treatment was chosen, respectively, in 48.9 and 2.8% of the medical cases. Treatment with radioactive iodine in 40.4 and 19.7% and anti-thyroid drugs (ATD) in 10.6 and 77.5% of cases.

All patients that underwent surgical treatment remain euthyroid at the end of 1 month, with no recurrence after 12 months. Average dose of iodine in TND was 9.5 mCi, with 89.4% achieving euthyroidism at 6 months, with 20% of recurrences at 12 months and 15.7% became hypothyroidism.

Average dose of iodine in GD was 11.5 mCi, achieving 71.4% euthyroidism in 6 months, 11.8% recurrences at 12 months and 16.7% became hypothyroidism. With ATD became Euthyroidism, 80% (for GD) and 81.5% (for DNT) with 25% recurrences 25% in GD and 45.7% in DNT at 12 months.

The treatment of choice was the surgical approach to TND and ATS for the GD, with recurrences rates similar to those of the literature <1% with surgery, 50% ATD and 20% with iodine.

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