Endocrine Abstracts

Aim: The aim of this study was to determine the relationship of the biochemical parameters serum phosphate, serum calcium, and serum parathyroid hormone levels with respect to parathyroid adenoma weight and volume in primary hyperparathyroidism.

Methods: Data were collected retrospectively from patients with primary hyperparathyroidism, who were diagnosed and followed between 2008 and 2013. 26 patients (female/male: 23/3) with a mean age of 51.3±12.7 years were enrolled into the study. Single parathyroid adenomas were identified from ultrasound examination reports. Preoperative calcium, phosphate, and parathyroid hormone levels were collected from charts. The data were analyzed using a multiple ANOVA, and a correlation coefficient was calculated. The level of significance was set at P≤0.05.

Results: With respect to adenoma volume, there was a significant correlation with serum calcium and parathormone levels (P=0.0001 and P=0.0001 respectively). There was no significant correlation between serum phosphate and adenoma volume. With respect to adenoma weight, there was a significant correlation with serum calcium and parathormone levels (P=0.0001 and P=0.0001 respectively). There was no significant correlation between serum phosphate and adenoma weight.

Conclusions: Preoperative serum calcium and parathormone levels may be able to predict adenoma weight and volume in primary hyperparathyroidism for a single adenoma.

Keywords: parathyroid adenoma, parathyroid hormone, primary hyperparathyroidism.