Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 P1107 | DOI: 10.1530/endoabs.35.P1107

ECE2014 Poster Presentations Thyroid Cancer (70 abstracts)

Effects of zoledronic acid monohydrate on cytotoxicity and apoptosis in BCPAP human papillary thyroid carcinoma cell line

Ilgın Yildirim Simsir , Gokcen Unal Kocabas , Banu Pinar Sarer Yurekli , Cigir Biray Avci & Lutfiye Fusun Saygili

Ege University Medical Faculty, Izmir, Turkey.

Thyroid cancer in Turkey is the most common endocrine neoplasm with an incidence of 3.7%. Papillary thyroid carcinoma is the most common thyroid malignancy in a similar manner. Papillary thyroid carcinoma creates 50–90% of differentiated thyroid carcinomas. There is available in subgroups with poor prognosis. Case-specific mortality of 2% at 5, 10, and 20 years, only 4 and 5%.

Mutations and re-arrangements in genes encoding proteins of the MAPK pathway for the development and progression of differentiated thyroid cancer, gain more, and more importance.

Bisphosphonates decrease tumor cell proliferation, reduce cell viability, stimulate apopitosis in tumor cell, inhibit cell adhesion and angiogenesis, and decrease metastatic potential in vitro.

We have established our hypothesis on the idea that this drug with minimal side effects has the potential to be an option instead of radioactive iodine treatment, or neoadjuvant prior to surgery or adjuvant therapy after surgery in patients with papillary thyroid carcinoma.

Zoledronic acid monohydrate with increasing doses of 10–100 μM was used on a papillary thyroid carcinoma cell line of human origin named BCPAP.

IC50 value with zoledronic acid monohydrate was found in first experiment at 48th h to be 55 μM, but second and third experiments failed. Therefore, apoptosis assays were not to be established. We investigate the reasons for inability to the result, and we will experiment again with a different papillary thyroid carcinoma cell line.

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