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Endocrine Abstracts (2014) 35 P370 | DOI: 10.1530/endoabs.35.P370

1Dokuz Eylul University, Izmir, Turkey; 2Ege University, Izmir, Turkey.

Context: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.

Objective: We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM).

Design and Setting: This was a cross-sectional study conducted in a university hospital.

Participants: A total of 61 pregnant women (30 GDM; 31 non-GDM) along with 41 age-matched non-pregnant controls participated in the study.

Main Outcome Measures: Plasma irisin, serum UCP1, insulin, fasting blood glucose (FBG), high sensitivity C-reactive protein (hs-CRP), and lipids were measured.

Results: Irisin levels were significantly higher and UCP1 levels lower in the GDM group, compared with both the non-GDM and the control groups (P<0.001). Irisin was inversely correlated with UCP1 (r=−0.42, P<0.001) and positively correlated with body mass index (BMI; r=0.25, P=0.008), hemoglobin A1c (r=0.22, P=0.026), homeostasis model assessment of insulin resistance (HOMA-IR; r=0.22, P=0.024), total cholesterol (r=0.39, P<0.001), and triglycerides (r=0.25, P=0.010). UCP1 was inversely correlated with BMI (r=−0.20, P=0.046), HOMA-IR (r=−0.25, P=0.011), total cholesterol (r=−0.27, P=0.006), and triglycerides (r=−0.29, P=0.003). Logistic regression analysis results indicated that irisin levels were not a significant risk factor for developing GDM. On the contrary, lower UCP1 levels were a risk factor independent of the other factors. Multiple regression analysis showed that BMI and UCP1 levels were directly related to irisin levels.

Conclusion: In patients with GDM, irisin signaling might be impaired leading to a compensatory increase in its levels.

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