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Endocrine Abstracts (2014) 35 P430 | DOI: 10.1530/endoabs.35.P430

Casa Cura Fabia Mater, Rome, Italy.


About 7% of pregnancies are complicated by diabetes, out of which 97.5% gestational diabetes (GMD), 2.5% pre-gestational diabetes. We investigated 29 women at their first pregnancy who had GMD medium risk factor in the absence of pre-existing thyroid pathologies. We divided them in two groups: the first 19 women (age 33.9 years) resulted affected by GMD (OGTT effected, according to Carpenter and C criteria), between pregnancy weeks 24–28; the second ten women (age 34.3 years) showed a normal OGTT (control group). In all the patients the thyroid hormones were investigated. Normal mean values of FT3 and TSH, negative TPO and low mean values of FT4 0.8 (0.71–1.85 ng/dl) have been evidenced in the first group. In the control group the mean value of FT4 was 1.04. During the pregnancy the low values of FT4 are normally due to a reduced iodine intake (mild thyroid failure) which may have possible effects on the fetal neurological system. In the first group, 11 patients, had been using iodized salt for more than 2 years (mean FT4 0.80 ng/dl), in the second group, eight patients, had never been using it (mean FT4 0.78 ng/dl); in the control group, five patients had been using iodized salt (mean FT4 1.1), and five had not (mean FT4 0.9). In the GMD the sole use of the iodized salt is not sufficient to keep the FT4 levels in the normal range and it is furthermore assumable that the insulin resistance may stimulate the inhibitor of the serum binding of thyroid hormones like the free fatty acids.

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