Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2014) 35 P625 | DOI: 10.1530/endoabs.35.P625


1CHC Bezanijska Kosa, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Diseases, CCS, Belgrade, Serbia; 3Institute for Biological Investigations ‘Siniša Stanković’, University of Belgrade, Belgrade, Serbia; 4Faculty of Medicine, Institute of Physiology, University of Belgrade, Belgrade, Serbia; 5Clinic for Obstetrics and Gynecology, CCS, Belgrade, Serbia.

Introduction: Insulin resistance and obesity are common features of polycystic ovary syndrome (PCOS) and both are independently associated with dysglycaemia. The aim of this study was to determine prevalence of dysglycaemia in obese women with PCOS.

Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We evaluated 100 obese women with PCOS (PCOS group: 28.99±3.05 kg/m2; 27.70±5.89 years) and 50 obese, age- and BMI-matched healthy women (control group: 28.13±3.77 kg/m2; 28.58±3.43 years). There was no difference in age and BMI between the groups (P=0.101 and P=0.137 respectively). Blood samples were collected in follicular phase of menstrual cycle for determination of basal glucose, insulin, total-cholesterol (TC), HDL-cholesterol (HDL) and LDL-cholesterol (LDL), and triglycerides. Two-hour oral glucose tolerance test (OGTT) with 75 g of glucose was performed in all subjects. Homeostatic model assessment (HOMA) was used to determine insulin resistance. Impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) were defined according to American Diabetes Association (ADA) criteria.

Results: PCOS had significantly higher basal glucose (5.8±0.7 vs 5.3±0.5 mmol/l; P=0.001), insulin (14.3±10.3 vs 9.6±5.2 mU/l; P=0.002), HOMA (3.6±2.5 vs 2.3±1.3; P<0.001); and triglycerides (1.1±0.4 vs 0.9±0.4 mmol/l; P=0.009). There was no difference in TC, HDL and LDL between the groups (P>0.05). PCOS had higher prevalence of IFG (50/100 (50%) vs 3/50 (6%); P<0.001) and IGT (43/100 (43%) vs 3/50 (6%); P<0.001), while there was no difference in prevalence of DM (5/100 (5%) vs 1/50 (2%); P=0.664).

Conclusion: In comparison to age and BMI matched healthy women, prevalence of impaired fasting glucose and impaired glucose tolerance was higher in our group of obese women with PCOS, while there was no difference in prevalence of diabetes mellitus.

Article tools

My recent searches

No recent searches.