Endocrine Abstracts

Postmenopausal osteoporosis is a condition that appears as a result of a sudden reduction in E₂ production by the ovaries. The earliest is manifested by the reduction of lumbar BMD; mostly consisted of trabecular bone. Proximal femur is built mostly of cortical bone, and so is aging more slowly, but femoral fracture more often lead to disability and death. The aim of the study was to check which from the anthropometric, hormonal and biochemical markers have the influence on the femoral neck BMD in postmenopausal women. The study included 325 healthy postmenopausal women (menopause >1 year ago) a random selected of women aged 50–60. The exclusion criteria were: smoking tobacco, HRT, ovariectomy, hyperparathyroidism, neoplasm, taking of anti cholesterol and antidiabetic drugs. BMI was calculated and waist circumference was measured. The femoral neck and total body BMD were performed using DXA method. Gynoid and android fat deposits were calculated. We had determined the concentrations of FSH, E₂, DHEAS, T, SHBG, insulin, leptin, adiponectin, IL6, TNF-α and glucose using commercial kits. HOMA. E₂:T ratio, FAI and FEI were calculated. We have shown a negative correlation between the femoral neck BMD and SHBG, and positive with body weight, BMI, % of body fat, android and gynoid fat deposits, waist, fasting glucose concentration and E₂:T ratio. The TNF α concentration correlate statistically significantly negatively with femoral neck BMD, and leptin-positively. After the multiple regression analysis we found that body weight, TNF-α, glucose concentration and E₂:T ratio are independent factors affecting femoral neck BMD in postmenopausal women. Conclusions: anthropometric factors stronger than hormonal influence on femoral neck BMD in postmenopausal women. The independent factors affecting femoral BMD is body weight (P=0.00000), E₂:T ratio (P=0.00149), TNF-α (P=0.0172) and glucose concentrations (P=0.0199).