Endocrine Abstracts

Material and method: i). Patients: A. ‘Classical’ Hashimoto thyroiditis (hyper-ATPO-emia, HT) =1293, B. thyroiditis with isolated hyper-ATG-emia, with normal ATPO (T-ATG) =92, C. thyroiditis ‘sero-negative’ (normal ATPO and ATG, pathology diagnosis) =11, D. idiopathic myxedema (hypothyroidism, no A,B,C) =86; E. control=1219. 2. Statistical analysis: X² test, z test.

Results: Total Immune Associations (excluding Graves Basedow Disease): HT=244 (18.87%, P<<0.001); T-ATG=23 (25%, P<<0.001); dif HTvTATG: NS, z=−1.4; ‘sero-negative’=1 (9.09%, NS); idiopathic myxedema=12 (13.95%, NS); control: 109 (8.94%). 2. Main IA (accordingly to the number): A. Graves-Basedow disease: TH: 161 (12.45%), T-TAG: 5 (5.43%), dif HTvT-ATG: important P<<0,001. B. Drug allergy: HT: 27, P<0.008, T-ATG=4, P=0,08. C. Vitiligo: HT=37, P<<0,001; T-ATG=only 2. D. Dermatitis: HT=37, P<<0,001; T-ATG=4 (NS). E. Immune ovaritis with precocious menopause: HT=17, P=0,006. F. Allergic Rhinitis: HT=13, P=0,006. G. Biermer anemia: HT=12; P=0,01. H. Asthma: HT=9, NS (control=10). I. Rheumatoid arthritis: HT=8, NS (control=19). J. Repetitive zona zoster: HT=7, P=0.04; K. Thrombophilia: HT=7, P=0.04. 3. Multiple associations: HT=70 (28.7% from HT IA); T-ATG=5 (21.74% from T-ATG IA). 4. In IA thyroid function and sex was the same as in other patients (in all z test, P=NS).

Conclusions: i). HT and T-ATG has immune associations with increased frequency. ii). The most significant and prevalent association are: Graves-Basedow, drug allergy, vitiligo, dermatitis, early menopause with immune ovaritis, allergic rhinitis, Biermer anaemia. iii). HT, T-ATG and idiopathic myxedema are not significantly associated with other immune conditions: rheumatoid arthritis, IDDM, B/C hepatitis. iv). Multiple immune associations are common.