Endocrine Abstracts

Background: Metabolic inflexibility in T2DM might result in reliance on free fatty acids (FFA) as substrates to maintain myocardial energy metabolism compared to lean and healthy controls. Thus, we investigated the effects of an acute suppression of circulating FFA on myocardial lipid content and left ventricular function in extreme phenotypes.Methods: T2DM patients (age: 56±11a; BMI: 28±3.5 kg/m2; HbA1c: 7.29±0.88%) and nine he...

Introduction: The aim of study was to analyse the effect of long-chain polyunsaturated higher ω-3 fatty acids (PUFAs) on the arterial stiffness parameters in patients with type 2 diabetes (T2DM) and cardiovascular autonomic neuropathy (CAN).Description of methods: The study involved 39 patients with moderate CAN (55.2±3.8 years, HbA1c 7.1±0.5%. The aorta (AIxao), brachial augmentation index (AIxbr), pulse wave velocity (PWV) were assessed ...

Recently, dipeptidyl peptidase-IV (DPP-IV) inhibitor, a major anti-hyperglycaemic agent, has received substantial attention as a possible therapeutic target for inflammatory diseases such as atherosclerosis. However, the direct molecular mechanisms through which DPP-IV inhibitor mediates anti-inflammatory effects in vascular endothelial cells have not been clarified. The effects of the DPP-IV inhibitor, gemigliptin, were analysed in human umbilical vein endothelial cells (HUVE...

Introduction: In preliminary results of our group, we detected an association between the mean nocturnal blood pressure and development microvascular complications. The objective was to evaluate possible nocturnal blood pressure cut off points in relation to the development or progression of retinopathy, microalbuminuria and arterial hypertension in type 1 diabetic patients.Methods: We designed a prospective observational study of 85 patients, clinically...

Introduction: There is strong evidence that adult survivors of childhood cancer have excess premature vascular morbidity and mortality, the pathophysiological mechanism of which remains unresolved.Methods: We undertook a cross sectional study to assess cardiovascular risk in long-term survivors of brain tumours following cranial irradiation compared with healthy matched controls. The following cardiovascular markers were measured: full lipid profile, fas...

Background: Although the issue of cardiovascular complications in type 2 diabetic patients is widely discussed and recommendations for such screening are known, it is less common to do so for type 1 diabetes mellitus (T1DM). Unfortunately, the mortality rate due to vascular complications is higher among type 1 diabetic patients than in the general population.Patients and methods: Seventy-six patients with T1DM history over 20 years were included in our s...

Lipocalin 2 has become an important biomarker for kidney disease and it is important to now understand it’s role in cardiomyopathy and understand it’s direct effects on the heart. Autophagy is now established as a critical determinant of cardiac function and here we investigated regulation of cardiac autophagy by lipocalin-2 and the functional consequences. After treating H9c2 cells with lipocalin-2 we used transmission electron microscopy, Western blotting and immun...

Background: The patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk due to the lifelong glucocorticoid therapy and the disease per se.Objective: To evaluate vascular and cardiac function in adults with CAH during optimal corticosteroid and fludrocortisone replacement therapy.Patients and methods: Cross-sectional study of 19 adults with CAH (age 23.7 years ±3.8; males 63%) compared to...