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17th European Congress of Endocrinology

Guided Posters

Pituitary–Neuroendocrinology and central salt regulation

ea0037gp.17.01 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5

Roumes Helene , Brossaud Julie , Lemelletier Alois , Moisan Marie-Pierre , Pallet Veronique , Redonnet Anabelle , Corcuff Jean-Benoit

Background: According to the literature, glucocorticoid receptor (GR) function is modulated by phosphorylation. Retinoic acid (RA) can activate some cytoplasmic kinases able to phosphorylate GR.Aim: As RA and glucocorticoids interact in neuronal cells, we investigated whether RA could modulate GR phosphorylation in such cells.Methods: HT-22 hippocampal cells were cultured 4d with or without dexamethasone (Dex, 10-6 M) or RA (10-6 M...

ea0037gp.17.02 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Glp-1 regulates the reproductive function and synchronizes the onset of the puberty in female rats

Iglesias Veronica Outeirino , Perez Marina Romani , Gomez Juan Fandino , Matias Lucas Carmelo Gonzalez , Ferrer Federico Mallo , Gago Eva Maria Vigo

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

ea0037gp.17.03 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Insulin-induced hypoglycaemia decreases IGF1 bioactivity in humans: a missing link to increased mortality in diabetic patients?

Sarem Zeinab , Assefa Biruhalem , Weickert Martin O , Adamidou Aikatarini , Frystyk Jan , Mohlig Matthias , Lieske Stefanie , Birkenfeld Andreas L , Pfeiffer A.F.H , Spranger Joachim , Arafat Ayman M

Background: The mechanisms underlying the association between severe hypoglycaemia and increased cardiovascular mortality among patients with diabetes mellitus are not fully understood. Our aim was to evaluate changes in GH/IGF1 axis during insulin-induced hypoglycaemia, as a possible link.Methods: Twenty-five healthy subjects, 12 obese participants (OP; 6/ 6; 34.4±1.7 kg/m2), and 13 healthy lean participants (LP; 6/ 7; 21.7±0.6 kg/m...

ea0037gp.17.04 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Copeptin reflects thermal strain during exercise in a hot environment

Stacey Mike , Woods David , Brett Stephen , Delves Simon , Britland Sophie Britland , Fallowfield Joanna , Allsopp Adrian

Background: Exertional heat illness (EHI) is an incapacitating and sometimes fatal phenomenon. It is associated with elevated core temperature (Tc), cardiovascular instability and the systemic inflammatory response syndrome. EHI-preventive guidelines recommend maintaining Tc ≤38 °C, an important thermoregulatory threshold above which vasomotor compensation plateaus and pronounced excursions in key pituitary and adrenal hormones occur. Copeptin, the C-terminal part o...

ea0037gp.17.05 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Hypernatremia and copeptin levels in the elderly hospitalised patient

Munter Gabriel , Liber Michal , Sonnenblick Moshe

Introduction/objective: Elderly patients have a higher prevalence of hypernatremia. Previous studies suggested that impaired ADH secretion contributes to development of hypernatremia in the elderly. Copeptin is the C terminal part of the ADH precursor and is more stable in plasma than ADH. The aim of this study was to detect demographic and clinical characteristics of the elderly hypernatremic patient hospitalized in the internal medicine ward, and to increase the understandin...

ea0037gp.17.06 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Predictors of response to fluid restriction in hyponatremic patients due to the syndrome of inappropriate antidiuresis

Lengsfeld Sophia , Winzeler Bettina , Nigro Nicole , Suter-Widmer Isabelle , Schutz Philipp , Arici Birsen , Bally Martina , Blum Claudine , Bock Andreas , Huber Andreas , Muller Beat , Christ-Crain Mirjam

Introduction: Fluid restriction (FR) is often the recommended first-line treatment for hyponatremia due to the syndrome of inappropriate antidiuresis (SIAD). However, FR not always leads to successful correction of hyponatremia, making predictive markers of treatment response desirable. The aim of this study was to evaluate routinely measured laboratory parameters, copeptin and pro-atrial natriuretic peptide (pro-ANP) as possible predictors of treatment success to FR.<p cl...

ea0037gp.17.07 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

Heterogenous patterns of recovery from adipsic diabetes insipidus in adult patients

Hernandez Martin Cuesta , Dineen Rosemary , Gupta Saket , Salehmohamed Ridhwaan , Thompson Christopher

Introduction: The natural history of adipsic diabetes insipidus (ADI) is not completely understood. Isolated case reports suggest occasional recovery of adipsia. We present the follow up of a cohort of 12 patients with ADI.Setting: National pituitary unit with interest in diabetes insipidus.Methods: ADI was identified by demonstrating absent thirst and AVP responses to hypertonic saline infusion. Results 12 patients with ADI were i...

ea0037gp.17.08 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

A study of hyponatraemia in acute medical admissions

Hendra Heidy , Graham Fiona , Catley Christine , Boitsova Tatjana , Rezk Tamer , Sankaralingam Suki , Abeygunasekara Sumith

Introduction: Hyponatraemia is the commonest electrolyte disorder in clinical practice and is closely associated with increased morbidity, mortality and length of hospital stay. It can be classified into mild (124–134 mmol/l), moderate (115–124 mmol/l), and severe (<115 mmol/l). The aim of the study was to determine the prevalence, aetiology, and management of hyponatraemia in general hospital.Methods: A total of 4139 acute medical admissio...

ea0037gp.17.09 | Pituitary–Neuroendocrinology and central salt regulation | ECE2015

The dopastatin BIM-23A760 distinctly influences key functional endpoints in different types of pituitary adenomas and normal pituitaries: role of somatostatin and dopamine receptor profile

Castano Justo P , Ibanez-Costa Alejandro , Lopez-Sanchez Laura M , Gahete Manuel D , Rivero-Cortes Esther , Vazquez-Borrego Mari Carmen , Galvez Maria Angeles , de la Riva Andres , Venegas-Moreno Eva , Jimenez-Reina Luis , Moreno-Carazo Alberto , Tinahones Francisco Jose , Maraver-Selfa Silvia , Japon Miguel A , Garcia-Arnes Juan Antonio , Soto-Moreno Alfonso , Webb Susan M , Kineman Rhonda D , Culler Michael D , Luque Raul M

Chimeric somatostatin (SST)/dopamine (DA) compounds, termed dopastatins, such as BIM-23A760, an agonist for SST (sst2 and ss5) and DA (D2) receptors, are emerging as promising new approaches to treat pituitary adenomas. However, their actions and mechanisms on the different types of pituitary tumours are still incompletely understood. Thus, the aim of this study was to analyse a set of key functional parameters (signaling pathways, hormonal expression and secretion, cell viabi...