Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 37 | ECE2015 | Next issue

17th European Congress of Endocrinology

Guided Posters

Pituitary–Basic and IGF-1

ea0037gp.18.01 | Pituitary–Basic and IGF-1 | ECE2015

Chronic stress decreases circulating endocannabinoid 2-arachidonoylglycerol in healthy human subjects

Yi Buqing , Nichiporuk Igor , Feuerecker Matthias , Schelling Gustav , Chouker Alexander

Increasing evidence indicates chronic stress plays an important role in a variety of health problems such as the development of autoimmune disease, and the results from mice studies suggest that the central endocannabinoid (eCB) system regulates endocrine and neuronal responses to stress. However, it is unclear how the eCB system responds to chronic stress in healthy humans. A 520-day isolation-and-confinement study simulating an interplanetary spaceflight mission to Mars prov...

ea0037gp.18.02 | Pituitary–Basic and IGF-1 | ECE2015

Neuroactive steroids as predictive markers for Alzheimer's disease

Vankova Marketa , Vejrazkova Daniela , Lukasova Petra , Bradnova Olga , Vacinova Gabriela , Dvorakova Katerina , Hill Martin , Vcelak Josef , Rusina Robert , Holmerova Iva , Bendlova Bela

Background and aims: Neuroactive steroids and their metabolites play an important regulatory role in the nervous system affecting the neuronal plasticity, stress response, learning, and memory. The aim of the study was to compare the steroid metabolome in AD patients and controls.Materials and methods: The study comprised of 48 AD patients (30 women and 18 men; age 73.8±9.54 years) and 33 matched controls (22 women and 11 men; age 68.2±5.94 yea...

ea0037gp.18.03 | Pituitary–Basic and IGF-1 | ECE2015

Regulation of sexually dimorphic growth of murine skeletal muscle by Stat5a and Stat5b

Paul Ryan , Elston Marianne , Conaglen John , McMahon Chris

GH regulates IGF1 predominantly through the intracellular signallers Stat5a and Stat5b. Inactivating mutations of Stat5b in humans result in severe growth retardation and low circulating IGF1 concentrations in males and females. In mice, however, there is only a loss of sexually dimorphic growth in males when Stat5b is deleted. No study has observed Stat5b−/− mice beyond 12 weeks or investigated any subsequent changes in skeletal muscle mass or IGF1 expr...

ea0037gp.18.04 | Pituitary–Basic and IGF-1 | ECE2015

A small hypothalamic volume correlates with impaired cognitive outcome in childhood onset craniopharyngioma on long-term follow up

Fjalldal Sigridur , Follin Cecilia , Gabery Sanaz , Petersen AEsa , Rylander Lars , Ekman Bertil , Johansson Aki , Osterberg Kai , Jansson Magdalena , Rovira Andrea , Erfurth Eva-Marie

Background: Hypothalamic damage caused by craniopharyngioma (CP) is related to memory deficits, disturbed attention, and impaired processing speed. This is the first study that aims to establish a structure to function relationship by assessing cognitive function in adult patients with childhood-onset (CO) CP along with volumetric analysis of the hypothalamus.Method: Forty-one (24 women) surgically treated CO-CP patients (median age at diagnosis; 11 year...

ea0037gp.18.05 | Pituitary–Basic and IGF-1 | ECE2015

Presence and functional actions of In1-ghrelin splicing variant reveals a potentially relevant pathophysiological role in human pituitary adenomas

Ibanez-Costa Alejandro , Gahete Manuel D , Rivero-Cortes Esther , Rincon-Fernandez David , Nelson Richard , Beltran Manuel , de la Riva Andres , Japon Miguel A , Venegas-Moreno Eva , Galvez Maria Angeles , Garcia-Arnes Juan A , Soto-Moreno Alfonso , Morgan Jennifer , Tsomaia Natia , Culler Michael D , Dieguez Carlos , Castano Justo P , Luque Raul M

Pituitary adenomas comprise a heterogeneous group of tumours causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin system comprises a complex molecular family with multiple functions, and some of its components have been linked to development of various endocrine-related cancers. In this work we aim at better delineating the patho-physiological significance of the ghrelin regul...

ea0037gp.18.06 | Pituitary–Basic and IGF-1 | ECE2015

Comparison of high-throughput platforms in evaluation of whole genome miRNA expression profiles in pituitary tissues

Butz Henriett , Darvasi Otto , Szabo Peter M , Liko Istvan , Pongor Lorinc , Czirjak Sandor , Racz Karoly , Patocs Attila

Introduction: There are three principal high-throughput methods that have been widely used to determine whole genome miRNAs expression profiles: i) microarrays, ii) qPCR based arrays, and iii) next generation sequencing (NGS). Our aim was to compare the results obtained from these platforms in normal and adenomatous pituitary samples and to validate the results by an independent sample set using qPCR.Material and methods: Using four normal pituitary (NP)...

ea0037gp.18.07 | Pituitary–Basic and IGF-1 | ECE2015

The hypothyroidism alters circadian clock expression in anterior pituitary gland

Bargi-Souza Paula , Peliciari-Garcia Rodrigo A , Previde Rafael Maso , Nunes Maria Tereza

The anterior pituitary gland occupies a central position in the hypothalamus–pituitary glands axes and secretes hormones involved in reproduction, growth, and metabolism. The plasma concentrations of pituitary hormones present fluctuations during the 24 h and are markedly altered during the hypothyroidism. The presence of an intra-pituitary circadian oscillator might be related to these oscillations; however, the molecular mechanism and the consequences of the hypothyroid...

ea0037gp.18.08 | Pituitary–Basic and IGF-1 | ECE2015

Role of miR-375 in oncogenesis of pituitary adenomas

Sanchez-Tejada Laura , Sanchez-Ortiga Ruth , Riesgo Pedro , Abarca Javier , Fajardo Carmen , Monjas Irene , Camara Rosa , Lamas Cristina , Pico Antonio

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...

ea0037gp.18.09 | Pituitary–Basic and IGF-1 | ECE2015

Molecular classification of pituitary adenomas

Pico Antonio , Sanchez-Tejada Laura , Sanchez-Ortiga Ruth , Camara Rosa , Lamas Cristina , Abarca Javier , Monjas Irene , Riesgo Pedro , Fajardo Carmen

Purpose: The 2004 edition of the WHO text ‘Histological typing of endocrine tumors’ classified pituitary adenomas (PA) on the basis of their histological and immunohistochemical characteristics. Recent advances on the knowledge of the molecular patterns of these tumours may allow establishing a molecular classification with higher accuracy and specificity than previous one.Methods: Within the pale of the multicenter Spanish Molecular Registry o...