Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 7–18% of women of reproductive age, according to different criteria. Metabolic disturbances related to PCOS include dyslipidemia, obesity, and insulin resistance (IR) and women with PCOS have higher prevalence of impaired glucose tolerance and type 2 diabetes mellitus in comparison with weight-matched women without the syndrome. Evidence indicates that regular practice of physical activity improves ...

Aim: To find early diagnostic criteria for metabolic syndrome (MS) in obese women in early pregnancy.Materials and methods: We examined 143 pregnant women aged from 19 to 43 years (31.0 (26.0; 35.0)) and divided them into three groups: MS group (n=55), risk group (one to two components of MS) (n=57), and control group (n=31). Laboratory examination included blood pressure (BP) monitoring, assessment of a lipid profile, glucose ...

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

Subclinical atherosclerosis is frequently present in women with polycystic ovary syndrome (PCOS). Metformin and liraglutide both improve metabolic control in PCOS, however they might exert different anti-atherosclerotic effects. We investigated the impact of these medications on the subclinical atherosclerotic changes of the arterial wall in PCOS patients.Results: 25 patients on metformin and 40 patients on liraglutide completed the study. Metformin impr...

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...