Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Guided Posters

Reproduction: Female and PCOS

ea0037gp.06.01 | Reproduction: Female and PCOS | ECE2015

Habitual physical activity is associated with lower prevalence of insulin resistance in women with polycystic ovary syndrome

Mario Fernanda , Graff Scheila , Spritzer Poli Mara

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 7–18% of women of reproductive age, according to different criteria. Metabolic disturbances related to PCOS include dyslipidemia, obesity, and insulin resistance (IR) and women with PCOS have higher prevalence of impaired glucose tolerance and type 2 diabetes mellitus in comparison with weight-matched women without the syndrome. Evidence indicates that regular practice of physical activity improves ...

ea0037gp.06.02 | Reproduction: Female and PCOS | ECE2015

Early diagnostics of insulin resistance in obese pregnant women

Kononova Oksana , Korotaev Aleksej , Platoshkin Erik , Pristrom Andrej , Vasilkova Volha

Aim: To find early diagnostic criteria for metabolic syndrome (MS) in obese women in early pregnancy.Materials and methods: We examined 143 pregnant women aged from 19 to 43 years (31.0 (26.0; 35.0)) and divided them into three groups: MS group (n=55), risk group (one to two components of MS) (n=57), and control group (n=31). Laboratory examination included blood pressure (BP) monitoring, assessment of a lipid profile, glucose ...

ea0037gp.06.03 | Reproduction: Female and PCOS | ECE2015

Characteristics of lipid profile in different phenotypes of polycystic ovary syndrome

Bjekic-Macut Jelica , Antic Ivana Bozic , Milutinovic Danijela Vojnovic , Ilic Dusan , Kastratovic-Kotlica Biljana , Stanojlovic Olivera , Andric Zoran , Macut Djuro

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...

ea0037gp.06.04 | Reproduction: Female and PCOS | ECE2015

Phenotypic characteristic of type 1 diabetic women with polycystic ovary syndrome

Lebkowska Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Otziomek Elzbieta , Milewski Robert , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

ea0037gp.06.05 | Reproduction: Female and PCOS | ECE2015

Cytokine expression in SAT and VAT from PCOS patients and control women; possible proinflammatory effect of testosterone depending on BMI – a preliminary report

Crisosto Nicolas , Echiburu Barbara , Perez-Bravo Francisco , Flores Cristian , Fuentes Cecilia , Cifuentes Mariana , Orellana Omar , Maluenda Fernando , Sir-Petermann Teresa

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...

ea0037gp.06.06 | Reproduction: Female and PCOS | ECE2015

Does finasteride, as well as metformin, improve insulin resistance in PCOS?

Diri Halit , Bayram Fahri , Simsek Yasin

Introduction: The effects of finasteride on insulin resistance and of metformin on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) are not clear. This study therefore compared the effects of finasteride, metformin, and finasteride plus metformin treatments on hormone levels, insulin resistance, and hirsutism score in women with PCOS.Subjects and method: Fifty-two patients with PCOS were randomly assigned to receive finasteride 5 mg/day...

ea0037gp.06.07 | Reproduction: Female and PCOS | ECE2015

The effect of metformin and liraglutide on markers of subclinical atherosclerosis in women with polycystic ovary syndrome

Jensterle Mojca , Jezovnik Mateja Kaja , Spirkoska Ana , Poredos Pavel , Janez Andrej

Subclinical atherosclerosis is frequently present in women with polycystic ovary syndrome (PCOS). Metformin and liraglutide both improve metabolic control in PCOS, however they might exert different anti-atherosclerotic effects. We investigated the impact of these medications on the subclinical atherosclerotic changes of the arterial wall in PCOS patients.Results: 25 patients on metformin and 40 patients on liraglutide completed the study. Metformin impr...

ea0037gp.06.08 | Reproduction: Female and PCOS | ECE2015

Plasma brain derived neurotrophic factor is decreased in women with polycystic ovary syndrome and related to the markers of endothelial dysfunction

Kowalska Irina , Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Lebkowska Agnieszka , Otziomek Elzbieta , Wolczynski Slawomir , Straczkowski Marek

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...