Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Guided Posters

Reproduction: Male and endocrine disruptors

ea0037gp.08.01 | Reproduction: Male and endocrine disruptors | ECE2015

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Ahern Tomas B , Huhtaniemi Ilpo T , Carter Emma L , Finn Joseph D , Pye Stephen R , O'Neill Terence W , Bartfai Gyorgy , Casanueva Felipe F , Forti Gianni , Giwercman Aleksander , Han Thang S , Kula Krzysztof , Lean Michael EJ , Pendleton Neil , Punab Margus , Vanderschueren Dirk , Wu Frederick C W

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 40–79 in eight ...

ea0037gp.08.02 | Reproduction: Male and endocrine disruptors | ECE2015

Deregulation of Sertoli and Leydig cells function in patients with Klinefelter syndrome as evidenced by testis transcriptome analysis

Ferlin Alberto , D'Aurora Marco , Nicola Marta Di , Garolla Andrea , Toni Luca De , Franchi Sara , Palka Giandomenico , Foresta Carlo , Stuppia Liborio , Gatta Valentina

Background: Klinefelter syndrome (KS) is the most common abnormality of sex chromosomes (47,XXY) and represents the first genetic cause of male infertility. Mechanisms leading to KS testis degeneration are still not completely defined but considered to be mainly the result of germ cells loss. In order to unravel the molecular basis of global testis dysfunction in KS patients, we performed a transcriptome analysis on testis biopsies obtained from six azoospermic non-mosaic KS p...

ea0037gp.08.03 | Reproduction: Male and endocrine disruptors | ECE2015

Infertile men have frequently Leydig cell dysfunction: study on hypogonadism, vitamin D and bone mass in 5177 subjects

Ferlin Alberto , Garolla Andrea , Selice Riccardo , Caretta Nicola , Pizzol Damiano , Foresta Carlo

Spermatogenic disruption is normally recognized by low sperm count and FSH levels. However, Leydig cell impairment is also frequent in subjects with primary testicular damage, as evidenced for example by reduced INSL3 and 25(OH)-vitamin D levels. The latter is caused by reduced expression of CYP2R1, a major enzyme involved in 25-hydroxylation of cholecalciferol. Furthermore, testosterone (T) production by the Leydig cells might be also impaired in men with primary spermatogeni...

ea0037gp.08.04 | Reproduction: Male and endocrine disruptors | ECE2015

Triclosan-induced breast cancer growth was antagonised by kaempferol, a phytoestrogen, via regulating cell cycle, migration and apoptosis related genes in MCF-7 breast cancer cells

Kim Seung-Hee , Hwang Kyung-A , Choi Kyung-Chul

Triclosan (TCS) is one of endocrine disrupting chemicals (EDCs) derived from toothpastes, deodorant and cleaning supplies. As a phytoestrogen, kaempferol (Kaem) is found at variety of vegetables. In this study, we examined anti-proliferative effects of Kaem in TCS-induced cell growth in MCF-7 breast cancer cells. In MTT assay, TCS (10−6 M) increased the cell viability of MCF-7 cells, while Kaem (50 μM) significantly reduced the cell viability compared to ...

ea0037gp.08.05 | Reproduction: Male and endocrine disruptors | ECE2015

Involvement of oestrogen receptor-α in λ-cyhalothrin and cypermethrin-induced cancer growth in BG-1 ovarian cancer cells expressing oestrogen receptor

Kim Cho-Won , Choi Kyung-Chul

Synthetic pyrethroids (SPs) are the most common pesticides which are recently used for indoor pest control. The widespread use of SPs has resulted in the increased exposure to wild animals and humans. Recently, some SPs are suspected as endocrine disrupting chemicals (EDCs) and have been assessed for their potential oestrogenicity by adopting various analyzing assays. In this study, we examined the estrogenic effects of λ-cyhalothrin (LCT) and cypermethrin (CP), the most ...

ea0037gp.08.06 | Reproduction: Male and endocrine disruptors | ECE2015

Bisphenol A affects amelogenesis by modulating enamel key genes expression

Jedeon Katia , Houari Sophia , Mcalpin Blake , Loiodice Sophia , Berdal Ariane , Babajko Sylvie

Bisphenol A (BPA) is a widespread endocrine disruptor commonly used by plastic industries. More than 95% of the world population contains BPA (ng/ml) in biological fluids raising the question of its activity and potential adverse effects. Anecdotally, molar incisor hypomineralisation (MIH), an enamel pathology affecting 15–18% of children, is increasing concurrently with ED related pathologies. Our previous data show that BPA impacts amelogenesis and generate similar enam...

ea0037gp.08.07 | Reproduction: Male and endocrine disruptors | ECE2015

Cord blood insulin-like peptide 3 is reduced in idiopathic cryptorchidism and inversely related to free bisphenol A: a marker and/or an actor of foetal exposure to endocrine disruptors?

Fenichel Patrick , Lahlou Najiba , Chevalier Nicolas , Coquillard Patrick , Panaia-Ferrari Patricia , Wagner-Mahler Kathy , Pugeat Michel , Brucker-Davis Francoise

Introduction: Cryptorchidism, the most frequent congenital malformation in full-term male newborns, increases risk of infertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested the role of both genetic and environmental factors. Physiological testicular descent is regulated by two major Leydig cell hormones: Insulin-like peptide 3 (INSL3) and testosterone.Methods and results: From a prospec...

ea0037gp.08.08 | Reproduction: Male and endocrine disruptors | ECE2015

Evidence of stimulation of pubertal development and suppression of growth rate in boys smoking marijuana in cigarettes

Jabeen Shagufta , Raja Ghazala Kaukab , Akram Maleeha , Ahmad Afzal , Qayyum Mazhar , Rizvi Shakeel Raza

Evidence indicates that normal pattern of progression of puberty is altered under certain conditions of stress, whereas growth rate is affected by sustained higher concentrations of cortisol, a marker of stress reactivity. Available data show that early teens commonly resort to use of drugs. The use of drugs may evoke stress responses, which may alter pubertal development and affect growth rate. Body weight (BW), height, BMI and plasma concentrations of LH, testosterone (T), G...