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Endocrine Abstracts (2015) 37 EP1064 | DOI: 10.1530/endoabs.37.EP1064

1Department of Endocrinology, Charles Nicolle University Hospital, Tunis, Tunisia; 2Department of Nephrology, Charles Nicolle University Hospital, Tunis, Tunisia.

Introduction: Systemic amyloidosis leads to functional compromise of various organs through infiltration of these tissues by amyloid protein.

The aim of this study was to determine the endocrine disorders in patients with systemic amyloidosis.

Methods: During the period from 1975 to 2006, we collected 580 patients with renal amyloidosis confirmed by histological exam. We selected 123 patients with hormonal exploration. 55 patients had thyroid function tests and 68 patients had adrenal function tests.

Results: There were 85 males and 38 females with a mean age of 49.6±18 years.

Seventeen patients had primary hypothyroidism (30.9%) and ten patients had primary adrenal insufficiency (14.7%). The diagnosis of hypopituitarism was established in 18 patients with a central hypothyroidism in 14 cases and an adrenocorticotropic hormone deficiency in four cases. None of the patients had a simultaneous achievement of two pituitary abnormalities but one patient had TSH deficiency associated with adrenal insufficiency. Goiter was observed in nine patients with hypothyroidism in four cases.

All patients with adrenal insufficiency, ten patients with low TSH and five cases of goiter had AA amyloidosis.

Conclusion: Endocrine disorders such as hypothyroidism and adrenal deficiency were frequent in renal amyloidosis. Therefore their screening is necessary for an early treatment to improve patient’s prognosis.

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