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Endocrine Abstracts (2015) 37 EP209 | DOI: 10.1530/endoabs.37.EP209

1Department of Clinical and Experimental Endocrinology, Medical University of Gdansk, Gdansk, Poland; 2Department of Analytical Chemistry, Gdansk University of Technology, Gdansk, Poland; 3Department and Clinic of Endocrinology, Diabetology and Isotope Therapy, Medical University of Wroclaw, Wroclaw, Poland; 4Department of Environmental Toxicology, Medical University of Gdansk, Gdansk, Poland; 5Independent Specialist of Gynaecology, Gdansk, Poland.

Plasticisers such as bisphenol A (BPA), bisphenol S (BPS), and phthalates (PAE) are commonly used in daily life in electronic equipment, cans, plastic food containers, and bottles. These substances can interact with oestrogen receptors as well as androgen receptors and therefore they are called endocrine disrupting chemicals (EDC). The aim of this study was to evaluate serum concentrations of BPA, BPS, and selected PAE in healthy women and women with polycystic ovary syndrome (PCOS). In total 191 women were studied. Eighty-six patients were diagnosed with PCOS according to the ESHRE/ASRME criteria. The healthy group consisted of 105 women without any endocrinopathies and not taking any hormonal contraceptives. Serum levels of prolactin, LH, FSH, 17OH-progesterone, total testosterone, DHEAS, insulin, and sex hormone binding globulin were measured. BPA and BPS concentration were analysed in all women’s sera using high pressure liquid chromatography method combined with mass spectrometry. Phthalates concentration were identified in biological samples using gas chromatography. Serum concentration of plasticisers were detected in 35% of samples for BPS and 90% of samples for BPA and PAEs respectively. The results of the analysis have pointed also to the higher levels of BPA in the sera of women with PCOS in comparison with healthy controls. There has been a strong positive correlation between serum concentrations of BPA and BPS with free androgen index and negative correlation with serum oestradiol level. Summarising, the results for plasticisers’ concentrations and their impact on the hormonal profile confirm their endocrine disrupting potential.

Disclosure: This work was partially supported by Polish Ministry of Science – grant number 01-0156/08.

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