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Endocrine Abstracts (2015) 37 EP494 | DOI: 10.1530/endoabs.37.EP494

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1Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Ophthamology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 3Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.


Background: Diabetic retinopathy (DR) is a clinically well-defined sight-threatening complication in type 2 diabetes. Angiopoietin 1 (Ang1) has been shown to promote endothelial cell survival without causing proliferation, stabilise endothelial interactions with surrounding support cells and can block the vascular permeability effects of vascular endothelial growth factor (VEGF). More recent data suggest that balance between these growth factors may affect vascular endothelial integrity and may be involved in the pathogenesis of diabetic retinopathy.

Aim of the study: To evaluate serum level of Ang1 in patients with DR and its relation to the severity of DR.

Methods: This is a cross sectional study comprised 75 patients with type 2 diabetes mellitus. They were divided into four groups, group A: 25 diabetic patients with proliferative DR (PDR), group B: 25 diabetic patients with non-proliferative DR (NPDR), group C: 25 diabetic patients with normal fundus, and group D: 50 healthy volunteers of matched age and sex.

Results: There was a high statistically significant reduction in serum level of Ang1 in diabetic patients (622.53+394.94) than the healthy control group (1637.00+253.50), P<0.001. Ang1 was significantly lower among group A (PDR) (330.80+145.19) than group B (NPDR) (489.60+226.89), and group C (1047.20+336.83). Correlation between Ang1 vs the other variables showed a highly significant negative correlation between Ang1 and HbA1c (P<0.001) and a significant negative correlation with albumin/creatinine ratio (ACR), P<0.02.

Conclusion: There is a significant reduction in serum Ang1 in patients with DR and correlated with the severity of DR. This reduction of Ang1 may reflect a role in the pathogenesis and progression of DR.

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