Endocrine Abstracts

The use insulin pump therapy (IPT) (continuous subcutaneous insulin infusion (CSII)) has increased dramatically in youth with type 1 diabetes (T1D) in the past decade.

Objective: Rate metabolic compensation of diabetes mellitus in children on IPT on the level HbA1c and self-control of glycaemia.

Methods: The examination of 19 children aged 12.55±3.75 years (boys/girls=13/6), with T1D, observed in ‘2nd City Children’s Hospital’ in Minsk. Up to IPT patients were on basal-bolus insulin therapy. Patients transferred to the IPT because of frequent uncontrolled hypoglycaemia. Evaluated the dose of insulin per kilogram body weight, blood glucose self-monitoring during the day, the presence of ketoacidosis, hypoglycaemic and hyperglycaemic conditions, the level of HbA1c.

Results: 100% of the patients complained of unstable blood glucose levels throughout the day. Clinical manifestation of diabetes observed in age 6.83±3.72 years. Longevity of diabetes this patients was from 0.5 to 16 years (4.91±4.10 years). Insulin dose per kilogram body weight on a basis of bolus insulin was 0.88±0.40 U/kg. HbA1c was 7.30±0.86%. Hypoglycaemic coma was in two children (10.53%). Self-monitoring of blood glucose was performed 8.9±3.6 times a day. Term of use pump 1.31±1.15 years. Five patients were in the ICU for more than 1 year (2.49±1.02 years). The IPT insulin dose per kilogram of body weight was 0.90±0.29 U/kg (P=0.005), HbA1c was 6.49±0.74% (P=0.002). Self-monitoring of blood glucose for IPT 7.15±2.89 times a day. IPT is not mentioned on the hypoglycaemic, severe hypoglycaemia, ketoacidosis, and hyperglycaemic conditions. The frequency change modes basal insulin dose during the day 4.8±1.5 times.

Conclusions: Children who are on insulin pump therapy during the year was a significant reduction in HbA1c at 11.10% (P=0.002), indicating that the long-term metabolic compensation in all age groups.