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Endocrine Abstracts (2015) 37 EP528 | DOI: 10.1530/endoabs.37.EP528


1Department of Endocrinology and Metabolic Diseases, University of Thessaly, Larissa, Greece; 2General Hospital of Larissa, Larissa, Greece; 3Department of Endocrinology, University of Ioannina, Ioannina, Greece; 4Department of Radiology, University of Thessaly, Larissa, Greece.

Introduction: Limited data exists regarding testosterone levels in type 1 diabetes mellitus (T1DM). The objective of this study was to evaluate serum sex steroids levels and body composition using dual energy X-ray absorptiometry method (DEXA) in male patients with T1DM.

Methods/design: We studied 36 male patients with T1DM (group D) (age: 35.3+11.66, years) and 35 healthy control (group C) matched for age, sex, and BMI. In both groups waist circumference (WC), HbA1c, total testosterone (TT), sex hormone-binding globulin (SHBG), LH, FSH, and IGF1 were measured. Calculated free (cFT) and bioavailable testosterone were estimated by standard formulas. Moreover, body composition was determined by DEXA and was calculated central abdominal fat (CAF).

Results: Mean BMI (kg/m2) and mean WC (cm) were similar in both groups (D: 25.8+3.44 vs C: 25.2+3.2, P=0.37) and (D: 94.5+9.6 vs C: 92.9+8.7, P=0.24). In group D, mean duration of DM was 16.8+10.5 years and mean HbA1c was 8.2+1.1%. We did not observe significant difference in TT, LH, and FSH levels between two groups. Group D had significantly lower SHBG (nmol/l) and IGF1 (ng/ml) levels than group C (39.57+7.5 vs 37.32+6.9, P=0.043 and 144.7+30.1 vs 180.2+27.1, P=0.031). Lower cFT (nmol/l) and bioT (nmol/l) levels were observed in group D compared to C but but did not reach clinical significance (0.608+0.136 vs 0.812+0.119, P=0.052 and 14.7+2.3 vs 15.2+2.5, P=0.057). Total fat and CAF were similar in both groups. CAF was negative correlated to TT and FT levels (r=−0.73, P=0.029 and r=−0.79, P=0.034). In group D, 2/36 (5.6%) had TT levels below the normal range after adjustment for age and BMI but none of group C.

Conclusion: Patients with T1DM seem to have a tendency to hypogonadism and its existence mainly occurred in association to obesity.

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