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Endocrine Abstracts (2015) 37 EP552 | DOI: 10.1530/endoabs.37.EP552

1S. de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar do Porto, Porto, Portugal; 2S. de Química Clínica, Centro Hospitalar do Porto, Porto, Portugal.

Introduction: The need to fast for the determination of lipid profile has been discussed in the past years, for several reasons – i) most of the day time is spent in a postprandial state; ii) the lipid concentrations seem to be only slightly affected by a normal meal; both fasting and postprandial can predict cardiovascular risk.

Aim: Determine the influence of normal food intake on the lipid profile of diabetic patients.

Methods: A total of 248 diabetic patients were included (49.6% male; median age 57 years, range 40–79 years), recruited between April/2013 and August/2014 from the Outpatient Diabetes Education Program of Hospital de Santo António, Centro Hospitalar do Porto. Clinical and analytical evaluation took place in two moments (fasting=t0; 2 h after a standard breakfast=t1), with measurements of total cholesterol (TC), LDL cholesterol (LDL-C), HDL-cholesterol (HDL-C) and triglycerides (TG). Paired LDL-C samples of patients with TG >400 mg/dl and outliers (≥3 S.D. from the mean) were excluded from the analysis.

Results: TG concentration increased between the two moments (median difference t1t0=6 mg/dl, P=0.002) but the TC, HDL-C, LDL-C and non-HDL-C did not change significantly (P: 0.69; 0.75; 0.06 e 0,60 respectively). Performing an analysis according to the two therapeutic goals for LDL-C proposed by the ATP III, we found that the proportion of patients with LDL-C t0≥100 mg/dl and LDL-C t1<100 mg/dl was 9.3% (5/54); and LDL-C t0≥70 mg/dl and LDL-C t1<70 mg/dl of 3.3% (3/91). Similarly, also a small percentage of patients with LDL-C t0 <100 mg/dl had values of LDL-C t1≥100 mg/dl (8.6%, 5/58). Considering the objective of 70 mg/dl, this percentage reached 14.3% (3/21).

Conclusion: The data presented question the need to fast for the determination of lipid profile. Further studies are needed to confirm these results and to demonstrate an association of postprandial lipid profile and cardiovascular risk in diabetic population.

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