ECE2015 Eposter Presentations Obesity and cardiovascular endocrinology (108 abstracts)
Intima–media thickness measurement of the carotid artery in patients with primary hyperparathyroidism
Dilek Tuzun , Ayten Oguz 1 , Murat Sahin 1 , Safa Ersen Ganidagli 2 , Didem Atay 2 , Hanife Bolat 2 , Cansu Yilmaz Cabioglu 2 , Ahmet Celik 3 & Kamile Gul 1
1Department of Endocrinology and Metabolism, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey; 2Department of Internal Medicine, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey; 3Department of Biochemistry, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Aim: The intima–media thickness (IMT) measurement of the common carotid artery is recognised as an important marker of systemic atherosclerosis. It may be useful in predicting the cardiovascular events, since it is related to the severity of coronary artery disease. The aims of this study were to analyse whether correlations exist between the IMT of the common carotid artery and the main clinical and biochemical parameters in patients with primary hyperparathyroidism (PHPT).
Patients and methods: Thirty patients with biochemically confirmed PHPT (group A, cases), 26 patients (group B, control group who have DM and/or HT), and 24 healthy volunteers (group C, healthy controls) were prospectively enrolled in the study. All patients underwent ultrasound examination and the IMT of each carotid artery were recorded.
Results: The final pathology showed a solitary parathyroid adenoma in all cases. Age, sex, mean IMT, and biochemical parameters, except serum calcium and PTH, did not differ significantly between groups (Table 1). But IMT is higher than case group compared to the other groups. But it was not statistically significant (P=0.05). In group A, DM and/or HT rate was 37.5% while 32.5% in group B and 0% in group C. There was positive significant correlation between serum calcium and IMT (r=324, P=0.003). But there was no correlation between IMT and serum parathyroid hormone and or serum phosphate.
| Group A | Group B | Group C | P | |
| Age (years) | 49.07±12.95 | 53.85±5.98 | 47.75±6.08 | 0.05 |
| Sex (female/male) (n) | 24/6 | 24/2 | 20/4 | 0.421 |
| Ca (mg/dl) | 11.45±1.04 | 8.88±0.44 | 9.02±0.43 | <0.001 |
| P (mg/dl) | 2.76±0.48 | 2.96±0.16 | 2.94±0.13 | 0.05 |
| PTH (pg/ml) | 229.98±182.84 | 41.38±3.62 | 42.87±2.67 | <0.001 |
| IMT (mm) | 0.83±0.14 | 0.76±0.19 | 0.72±0.51 | 0.05 |
| Group A, cases; group B, controls with DM and/or HT; group C, healthy controls; PTH, parathyroid hormone; IMT, intima–media thickness of the common carotid artery. | ||||
Conclusion: Several cardiovascular risk factors have been reported in patients with PHPT since both calcium and PTH are related to heart function. Our results suggest that hypercalcaemia may represent a risk of carotid atherosclerosis in patients with PHPT.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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