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Endocrine Abstracts (2015) 37 EP972 | DOI: 10.1530/endoabs.37.EP972

Department of Endocrinology and Metabolism, Ankara Training and Research Hospital, Ankara, Turkey.

Pentraxin 3 (PTX3) is produced from several cell types in case of inflammation. PTX3 has been investigated in several autoimmune diseases. As Hashimoto disease is an autoimmune disease of thyroid, we investigated the role of PTX3 levels in patients with Hashimoto disease.

Objective: The aim of this study was to investigate the relationship between PTX3 and autoimmune thyroiditis.

Methods: The study subjects were classified as four groups. Group 1: Control group included 42 euthyroid healthy women with negative autoantibody. Group 2 included 27 euthyroid women with positive autoantibody. Group 3 included 46 subclinic hypothyroid women with positive autoantibody (TSH 5–10 mU/L). Group 4 included 39 hypothyroid women with positive autoantibody (TSH >10 mU/L). PTX3 values were measured with ELISA method.

Results: No significant difference was found for PTX3 level between patients with autoimmune thyroiditis and control group. The highest PTX3 level was determined in fourth group. There was a positive relation between PTX3 and TSH level in all groups. There was also a positive correlation between PTX3 and cortisol level.

Conclusion: This is the first study investigating the relationship between PTX3 and autoimmune thyroid disease. Although PTX3 levels were positively associated with TSH levels, we couldn’t find any difference in PTX3 levels between our groups.

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