ECE2015 Guided Posters Reproduction: Female and other (7 abstracts)
Incretin release in a different state of testosterone level among lean PCOS women – case control study
Sandra Mrozinska 1 , Tomasz Milewicz 2 , Iwona Rogatko 3 , Marta Kialka 4 , Magdalena Spalkowska 5 , Kamila Migacz 6 , Aleksandra Kowalczuk 7 , Agnieszka Kawula 8 & Anna Galuszka-Bednarczyk 9
1Department of Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland; 2Department of Gynecological Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland; 3Department of Clinical Biochemistry, Polish-American Institute of Pediatrics, Cracow, Poland; 4Department of Gynecological Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland; 5Department of Dermatology, Collegium Medicum, Jagiellonian University, Cracow, Poland; 6Department of Gynecological Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland; 7Department of Gynecological Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland, 8Specialist Hospital, Rybnik, Poland; 9Department of Gynecological Endocrinology, Collegium Medicum, Jagiellonian University, Cracow, Poland.
Introduction: Incretins are peptide hormones, responsible for 70% of the insulin release after oral glucose intake. An impaired incretins secretion was noted in several conditions involving insulin resistance, including polycystic ovary syndrome (PCOS), known as the state with increased testosterone level. This paper considers a possible relationship between the level of free androgen index (FAI) and glucose-dependent insulinotropic peptide (GIP) among lean women affected by PCOS. To our knowledge, no previous study has evaluated the matter so far.
Case control study: 50 lean women (BMI=20.76±1.83) were enrolled to the study and divided into two groups according to the FAI level. Group A consisted of 25 patients with FAI <5 and group B consisted of 25 patients with FAI >5. All subjects underwent standard meal test. Serum GIP concentration was determined both at fasting and at 60 min of the test. Calculations were computed in the Statistica Program.
Results: Mean GIP was significantly higher in group 2 before and after meal test (Mann-Whitney’s U test; P=0.006). Likewise, group 2 exhibited higher values of medians. Spearman’s test indicated significant correlation between FAI and GIP levels at 0′ and 60′ in total study population (0′: P=0.008; 60′: P=0.049). The absence of the significant correlation was observed in each group. It might be a consequence of the limited number of patients.
Conclusion: Excess androgen activity might be a vital factor contributing to alter secretion of incretins in lean PCOS women. An increased GIP levels may induce hyperinsulinaemia and play an additive to insulin resistance role in progression to T2DM.
Volume 37
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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