ECE2015 Guided Posters Calcium, Vitamin D and Bone (1) (9 abstracts)
Hypocalcaemia development in patients operated for primary hyperparathyroidism: can it be predicted preoperatively?
Cafer Kaya 1 , Abbas Ali Tam 1 , Ahmet Dirikoç 1 , Aylin Kılıçyazgan 2 , Mehmet Kılıç 3 , Şeyda Türkölmez 4 , Reyhan Ersoy 5 & Bekir Çakır 5
1Department of Endocrinology and Metabolism, Ataturk Training and Research Hospital, Ankara, Turkey; 2Department of Pathology, Yildirim Beyazit University, Ankara, Turkey; 3Department of General Surgery, Yildirim Beyazit University, Ankara, Turkey; 4Department of Nuclear Medicine, Ataturk Training and Research Hospital, Ankara, Turkey; 5Department of Endocrinology and Metabolism, Yildirim Beyazit University, Ankara, Turkey.
Introduction: Primary hyperparathyroidism (PHP) is a highly prevalent disease, which is treated most effectively by surgery. Postoperative hypocalcaemia, a morbidity of surgical treatment of parathyroidism, can prolong the hospital stay. The aim of this study was to identify the factors predictive of hypocalcaemia and hungry bone syndrome (HBS) in patients who undergo parathyroidectomy due to PHP.
Materials and methods: Preoperatively and on days 1 and 4, and month 6 postoperatively, the patients’ laboratory data including parathyroid hormone (PTH), calcium, phosphorus, 25-hydroxyvitamin D3 (25-OHD), albumin, magnesium, alkaline phosphatase (ALP), blood urea nitrogen (BUN), and TSH, free T3 and free T4 levels; and neck ultrasonography (US) and bone densitometry findings were recorded.
Results: Hypocalcaemia was observed in 63 (38.4%) of 164 patients on day 1 following parathyroidectomy. On the postoperative 6th month, permanent hypocalcaemia was present in 10 (6.1%) patients. HBS was observed in 22 (13.4%) of the patients who underwent parathyroidectomy due to PHP. Among the PHP-related parathyroidectomy patients, postoperative hypocalcaemia was observed more frequently among patients with parathyroid hyperplasia and those with osteoporosis. On the other hand, PTH, ALP, and BUN values were higher among patients who developed HBS. Additionally, HBS was observed more frequently among osteoporosis and parathyroid hyperplasia patients and those who had thyroidectomy simultaneously with parathyroidectomy.
Conclusion: As a result, a more thorough preoperative follow-up is recommended for patients with risk factors for hypocalcaemia and HBS development.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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