Endocrine Abstracts

Peptide hormones stimulate responses in target tissues by triggering enzyme activation inside cells and thus the generation of ‘second messenger’ molecules. Two of the most important second messengers in endocrinology are cAMP, whose production is stimulated by activation of Gαs G proteins in response to hormones such as TSH and ACTH, and phosphatidylinositol-3,4,5-trisphosphate (PIP3), generated by phosphatidylinositol-3-kinase (PI3K) in r...

Robert Semple is a Reader in Endocrinology and Metabolism and Honorary Consultant Endocrinologist at the University of Cambridge, UK. He read Biochemistry and then Medicine at the University of Cambridge before internal medical posts in London. He returned to Cambridge for specialist training in Diabetes and Endocrinology, interrupted by doctoral studies with Prof. Sir Stephen O’Rahilly, focussing on transcriptio...