Endocrine Abstracts

Transcription factors (TFs) regulate gene expression by interacting with chromatinized DNA response elements (REs). Access to these elements is dramatically restricted by chromatin organization, and modification of the nucleoprotein structure to allow factor binding is a key feature of cell selective gene regulation (Molecular Cell 29:611, 2008; Molecular Cell 43:145, 2011). Local transitions in chromatin access (often characterized as DNaseI hypersensitive sites (DHSs)) are o...

Dr Hager received his PhD in Genetics at the University of Washington, and pursued postdoctoral studies with Dick Epstein at the Institut de Biologie Moleculaire in Geneva and with Dr William Rutter at the University of California-San Francisco. After moving to the NIH, he developed the mouse mammary tumor virus (MMTV) system as a model to study hormonal regulation of gene expression, and utilized this system to descr...