Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2015

Edinburgh, UK
02 Nov 2015 - 04 Nov 2015

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2-4 November 2015, Edinburgh, UK Further information

Poster Presentations

Growth and development

ea0038p140 | Growth and development | SFEBES2015

Hormonal control of β-cell proliferation in fetal ovine pancreatic islets in vitro

Harris Shelley E , Kelly Amy , Davis Melissa A , Anderson Miranda , Forhead Alison J , Limesand Sean W

Hormonal control of pancreatic β-cell development in the fetus during late gestation remains unclear. In fetal sheep hypothyroidism causes an increase in pancreatic β-cell mass in association with increased plasma insulin and leptin concentrations. This study investigated the effects of triiodothyronine (T3), insulin and leptin on proliferation rates in fetal ovine pancreatic β-cells in vitro.All procedures were approve...

ea0038p141 | Growth and development | SFEBES2015

Inter-correlations between placental genes regulating foetal glucocorticoid exposure and IGF2 in maternal severe obesity: a mechanism for higher birthweight?

Mina Theresia , Riley Simon , Norman Jane , Reynolds Rebecca

Background: Maternal obesity in pregnancy associates with higher birthweight. A key pathway is through placental regulation of hormones controlling foetal growth. As excess foetal glucocorticoid exposure associates with lower birthweight and since placental Insulin-like Growth Factor (IGF2) may be modulated by glucocorticoids, we hypothesised that the expression profiles of placental genes leading to reduced glucocorticoid exposure and increased IGF2 mRNA level correlate with ...

ea0038p142 | Growth and development | SFEBES2015

Human foetal adrenal gland development and effects of maternal smoking

Johnston Zoe C , Filis Panagiotis , Bellingham Michelle , O'Shaughnessy Peter J , Fowler Paul A

Introduction: The human foetal adrenal gland (HFA) is a highly active endocrine organ, producing large amounts of DHEA and DHEAS. Our understanding of HFA development is limited, however, and species differences mean that animal models are only of partial use. Maternal cigarette smoking is known to increase the post-natal risk of health complications of the foetus, and the mechanisms involved may include effects on the HFA.Aim: To examine normal HFA deve...

ea0038p143 | Growth and development | SFEBES2015

Vitamin D promotes myogenic differentiation and induces an antifibrotic phenotype in primary cultures of skeletal muscle derived satellite cells and fibroblasts

Daoud Amanda , Kim Irene , Norris Keith , Ferrini Monica , Artaza Jorge

Purpose of study: Skeletal muscle wasting is a serious public health problem associated with aging, chronic kidney disease, and AIDS. Vitamin D (VD) is most widely recognised for its regulation of calcium and phosphate homeostasis in relation to bone development and maintenance and for its synergistic effects on target organs such as PTH glands. Recently, it has been shown to improve muscle performance and reduce falls in VD deficient older adults. However, little is known of ...

ea0038p144 | Growth and development | SFEBES2015

Hypothyroidism, altered leptin and c-reactive protein synthesis characterised pregnancy exposed to genistein

Awobajo Funmileyi

This study examined the mechanism by which genistein produced adverse effects in pregnant laboratory rats. Pregnant rats were divided into control (Con) and genistein (Gen) force fed (2 mg/kg) groups. At terminal gestation day (GD) ranging from 0 to 20, the rats were sacrificed, and blood samples and amniotic fluids were collected. Thyroid hormone, C-reactive protein (CRP) and leptin assay was carried using the blood samples. Leptin was also assayed in the placenta and amnioti...