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Endocrine Abstracts (2015) 38 APW1.3 | DOI: 10.1530/endoabs.38.APW1.3

SFEBES2015 Applied Physiology Workshop Evolving model systems for complex tissues (3 abstracts)

Cell replacement and regeneration of β cells as novel therapy for diabetes

Neil Hanley 1,


1University of Manchester, Manchester, UK; 2Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.


The last couple of years have seen an advance in generating human β-cells from pluripotent stem cells. It is now clear that cells of greatly increased maturity can be obtained from robust protocols. In addition to improving the prospects of cell replacement therapy, these developments allied to greater understanding of how human β-cells are first generated in the body are allowing development of more complex model systems. These model systems are likely to be important in gaining mechanistic understanding of developmental monogenic causes of diabetes (e.g. maturity onset diabetes of the young, and permanent or transient neonatal diabetes) and deciphering the relevance of genome-wide association studies in type 2 diabetes. Recent advances and data will be discussed.

Volume 38

Society for Endocrinology BES 2015

Edinburgh, UK
02 Nov 2015 - 04 Nov 2015

Society for Endocrinology 

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