Endocrine Abstracts (2015) 38 P290 | DOI: 10.1530/endoabs.38.P290

Influence of deuterium depleted water on indicators of prooxidant-antioxidant and detoxifying systems in experimental diabetes

Stepan Dzhimak, Alexander Basov, Lilia Fedulova & Elena Kotenkova

The Gorbatov’s All-Russian Meat Research Institute, Moscow, Russia.

Studying the effect of deuterium depleted water (DDW) on isotope (D/H) composition and condition of an antioxidant-prooxidant plasma and lyophilized tissues of internal organs (liver, kidney) balance appropriate indicators in rats were compared: in group 1 (n=15) consumed mineralized water (150 ppm), which by a single intraperitoneal injection of alloxan (at a dose of 17 mg/100 g body weight) was established experimental model of diabetes; group 2 (n=15) consumed mineralized water (40 ppm) for 30 days before creation of a similar model of experimental diabetes. On day 5 after modeling of alloxan diabetes in rats of both groups was observed increase in blood glucose level in 2.2 times, increase in the activity of enzymes (aspartate aminotransferase, alanine aminotransferase), characterizing cytolytic processes, increasing concentrations of creatinine, bilirubin and urea.

It was found that in group 2 on 45 day drinking 40 ppm water deuterium content in the blood plasma was reduced to 99.7±0.4 ppm (P<0.05), which was on 34.1% lower in comparison with the group 1 (P<0.05). In addition, the integral index of the functioning of the low molecular unit prooxidant-antioxidant blood system (COMBer – patent number 2236008 RU) in group 1 was 17.9% higher than in group 2 (P<0,05), indicating that the perspective of DDW using at the complex correction of metabolic disorders in the antioxidant system, observed during the development of diabetes.

Also observed a decrease in the concentration of endogenous toxic substances in the blood of rats from group 2, which was confirmed by lower (on 27.1%, P<0.05) integral index values of endogenous intoxication in group 2 (94.2% hypercatabolism) compared with the group 1 (129.3% hypercatabolism), that indicating on increased functional activity of detoxifying system and increasing of nonspecific organism resistance when DDW administered in the rats diet.

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