Endocrine Abstracts (2015) 38 P377 | DOI: 10.1530/endoabs.38.P377

Effects of oral, injectable, and implant hormonal contraception on serum levels of iron, ferritin, copper, ceruloplasmin and vitamin E

Titilola Samuel, Olufemi Morakinyo, Adepeju Balogun, Jo Olamijulo & Olubunmi Magbagbeola

College of Medicine, University of Lagos, Idiaraba, Lagos, Nigeria.

Recently there has been reports that the administration of hormonal contraceptives alter the metabolic processes and micronutrients levels. Meanwhile some of these micronutrients are cofactors and or coenzymes of enzymes and are involved in important metabolic pathways. We compared the influence of three contraceptive methods (oral contraceptive, injectables and implants) on serum levels of Iron, ferritin, copper, ceruloplasmin and Vitamin E, using standard methods. Blood samples were collected from women aged 15–49 years attending Family planning clinics within Lagos metropolis and obstetrics and gynaecology department of the Lagos University teaching Hospital, idi-araba, Lgaos, 50 implant users, 100 injectable users, 100 oral contraceptive users were compared with 50 age matched controls. Results found that iron ferritin, copper, ceruloplasmin and vitamin E were significantly higher P<0.05 in all the hormonal contraceptive users compared with control and baseline. Changes in tissue or serum levels or bioavailability of these micronutrients might play a significant role in health risk and might be involved in the pathogenesis of some disorders.

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