Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Oral Communications

Cardiovascular endocrinology

ea0041oc7.1 | Cardiovascular endocrinology | ECE2016

Lipoprotein lipase DNA methylation: cause or consequence of metabolic disorders

Castellano-Castillo Daniel , Moreno-Indias Isabel , Queipo-Ortuno Maria Isabel , Fernandez-Garcia Jose Carlos , Alcaide-Torres Juan , Tinahones Francisco , Cardona-Diaz Fernando

Introduction: DNA methylation is one of the epigenetic mechanisms existing to regulate gene expression. It is believed that methylation of DNA is susceptible of change by environmental and nutritional factors. Thus, epigenetics provides a mechanism which may explain the etiology of some metabolic disorders and obesity.Aim: The aim of this study is to analyze the DNA methylation level of several lipoprotein lipase (LPL)-promoter-CpG island in human viscer...

ea0041oc7.2 | Cardiovascular endocrinology | ECE2016

Cardiovascular and metabolic morbidity in adult patients with classic congenital adrenal hyperplasia

Paizoni Luisa , Schaefer Kerstin , Thomas Evelina , Reisch Nicole

Background: Several studies suggest health problems in adult patients with CAH. However, data is inconsistent and based on small and relatively young cohorts.The aim of this study was to analyze the metabolic and cardiovascular health in a cohort of 90 adult patients with classic CAH.Subjects and methods: Participants included 90 patients with classic CAH: age range 18–62 years (mean 32.9±10.5, median 29.2) 39 male, 51 fe...

ea0041oc7.3 | Cardiovascular endocrinology | ECE2016

Muscle strength in Cushing’s syndrome: cross-sectional evaluation of the German Cushing’s registry

Berr Christina M , Quinkler Marcus , Stieg Mareike , Deutschbein Timo , Osswald Andrea , Schmidmaier Ralf , Reisch Nicole , Ritzel Katrin , Blaser Rainer , Fassnacht Martin , Stalla Gunter , Beuschlein Felix , Reincke Martin

Background: Endogenous Cushing’s syndrome (CS) is rare with an estimated yearly incidence of 1–3 patients/million. CS describes a group of diseases that have in common an excess secretion of glucocorticoids which results in a characteristic clinical phenotype. Severe courses of Cushing’s syndrome are characterized by a break-down of protein catabolism translating into clinical consequences including muscle weakness. While remission of CS is achievable by surgica...

ea0041oc7.4 | Cardiovascular endocrinology | ECE2016

Cortisol autonomy is associated with increased risk of cardiovascular events and mortality in patients with adrenal incidentalomas: beneficial effects of a selective use of adrenalectomy

Reimondo Giuseppe , Mbachu Elena , Pellegrino Micaela , Pia Anna , Pepe Emanuele , Borretta Giorgio , Terzolo Massimo

Introduction: Cortisol autonomy may be frequently demonstrated in patients with adrenal incidentaloma and this has been associated to increased cardiovascular (CV) risk. However, only few data are available on CV events and related mortality in such patients. Aims of the study were: 1) to stratify CV events and mortality by the degree of cortisol secretion; 2) to evaluate the effect of adrenalectomy on CV events and mortality.Methods and Design: Data of ...

ea0041oc7.5 | Cardiovascular endocrinology | ECE2016

Hypothyroidism and levothyroxine treatment is associated with increased mortality in heart failure patients

Nygaard Andersen Mette , Schjerning Olsen Anne-Marie , Khalid Usman , Lund Kristensen Soren , Faber Jens , Torp-Pedersen Christian , Gislason Gunnar , Selmer Christian

Introduction: Hypothyroidism has detrimental effects on the cardiovascular system but controversy remains over the benefit of levothyroxine substitution in heart failure (hf). The aim of this register based cohort study was to examine the effects of levothyroxine treatment on all-cause mortality in patients with hf.Methods: The study cohort comprised all Danish citizens aged ≥18 years admitted with hf in 1997–2012 and still alive 30 days after...