Endocrine Abstracts

Wound healing and tumour stroma formation are associated with angiogenesis and require interactions of various different cell types. We and others have shown that mesenchymal stem cells (MSCs) differentiate into fibroblast-/pericyte-like cells and secrete proangiogenic factors. Thyroid hormones act as proangiogenic modulators mediated by non-genomic mechanisms via cell surface receptor integrin αvβ3. The aim of this study is to evaluate the stimulatory activity of T3...

: Inflammation and several oxidative processes are modulated by Selenium (Se) trough the selenoproteins. Se deficiency has been associated with thyroid autoimmune diseases and hypothyroidism, while Se-supplementation reduces antibodies titles and ameliorates ultrasound pattern of the gland.Aim of the current study, is to study the molecular effects of Se-supplementation in thyroid follicular cells (FRTL5).FRTL5 cells have been star...

Objective: Thyroid hormones have essential role in regulation of cellular growth, development and metabolism. Although genetic variants seem to be an important determinant of thyroid hormone levels the data about involved genes are still limited. Therefore, in order to determine genetic variants underlying thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) plasma level we performed a genome wide association study (GWAS) in Croatian subjects...

Background: Graves’ orbitopathy (GO) is a severe organ-specific autoimmune inflammatory ocular complication most often associated with Graves’ disease (GD). Besides the cosmetic problems these patients develop, GO may also cause severe eye complications threatening the vision of the patient. Additionally, GO complicates the treatment of patients with GD, making the identification of Graves patients at risk for eye disease before they develop symptoms a critical step ...

Introduction: So far, only two representatives of thyronamines, namely 3-iodothyronamine (3-T1AM) and the iodine–free thyronamine (T0AM), have been detected in vivo. While intensive research is done on the (patho-) physiological function of 3-T1AM, the physiological role of T0AM is poorly studied. Conflicting data have been reported for the acute cardiac effects of T0AM. This project therefore determined whet...