ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Relationship of insulin sensitivity with HOMA-IR and QUICKI index in euthyroid woman with Hashimoto’s
Muge Bilge 1 , Mine Adas 2 , Aylia Yesilova 1 & Aysen Helvaci 1
1Internal Medicine Clinic, Okmeydani Training and Research Hospital, Istanbul, Turkey; 2Endocrinology Department of Internal Medicine Clinic, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Objective: It is recognized that autoimmun thyroid dysfunction is associated with weight and metabolic changes, insulin resistance and type 1 diabetes. In this study, we aimed to investigate whether thyroid autoimmunity had an effect on insulin sensitivity in euthyroid woman with Hashimoto’s thyroiditis.
Methods: Forty-seven newly diagnosed euthyroid woman with Hashimoto’ thyroiditis with a mean age of 43 years were included in the study. The control group consisted of 39 age and BMI matched healthy subjects. Thyroid hormones and antibodies, thyroid peroxidase antibody (TPOAb) and thyroglobuline antibody (TGAb), insulin, glucose, c-peptid, HbA1c and uric acid levels, and Homeostasis Model Assessment İnsulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) parameters were measured in all the subjects.
Results: No significant correlation was observed between thyroid autoimmunity and HOMA-IR and between thyroid autoimmunity and QUICKI in both groups (Table 1).
| Patient | Control | P | |
| Age | 43.62±8.64 | 41.68±7.43 | NS |
| TSH (μIU/ml) | 2.1±1.61 | 2.0±1.01 | <0.001 |
| Free T4 (ng/dl) | 1.15±0.32 | 1.13±0.13 | NS |
| Free T3 (ng/dl) | 2.97±0.49 | 3.0±0.39 | NS |
| TPOAb (IU/ml) | 288.43±291.17 | 8.81±5.20 | <0.001 |
| TGAb (IU/ml) | 323.17±651.96 | 16.98±12.36 | <0.001 |
| Uric acid (mg/dl) | 4.09±1.09 | 3.94±0.93 | NS |
| Fasting glucose (mg/dl) | 86.95±10.83 | 88.64±9.61 | NS |
| Fasting insülin (μg/dl) | 11.28±6.68 | 11.31±13.30 | NS |
| C peptid (ng/ml) | 2.38±1.05 | 2.44±1.36 | NS |
| HbA1c (%) | 5.5±0.37 | 5.42±0.50 | NS |
| BMI | 28.37±6.06 | 28.80±9.28 | NS |
| HOMA-IR | 2.41±1.66 | 2.44±2.90 | NS |
| QUICKI index | 0.34±0.03 | 0.35±0.03 | NS |
| NS: Not significant. | |||
Conclusion: Thyroid autoimmunity seem to not have a potential effect on insulin sensitivity in patients with newly diagnosed euthyroid Hashimoto’s.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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