Assessment of thyroid function during the three trimesters of pregnancy in alexandria region (Egypt)

F E Amara; M H Megalaa; Y I Oraif; M G Moawad; M A Korani; M F Amara; S El-Sheikh

doi:10.1530/endoabs.41.EP1077

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Endocrine Abstracts (2016) 41 EP1077 | DOI: 10.1530/endoabs.41.EP1077

ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)

Assessment of thyroid function during the three trimesters of pregnancy in alexandria region (Egypt)

F E Amara ¹ , M H Megalaa ¹ , Y I Oraif ² , M G Moawad ¹ , M A Korani ³ , M F Amara ¹ & S El-Sheikh ¹

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¹Department of Internal Medicine, Alexandria University, Alexandria, Egypt; ²Department of Gynaecology and Obstetrics, Alexandria University, Alexandria, Egypt; ³Department of Internal Medicine, Menofia University, Alexandria, Egypt.

Introduction: Pregnancy is associated with significant reversible changes in thyroid functions due to certain hormonal changes e.g. HCG and estrogen.

Objective: To study thyroid functions in different trimesters of pregnancy compared to control age matched non pregnant women.

Design and Methods: Cross sectional study of 90 pregnant women divided into three groups in the three trimesters of pregnancy compared to 30 ages matched non-pregnant women. Study of FT3, FT4, TSH and TPO using COBAS analyser.

Results: In general, our study showed significant differences between pregnant and non-pregnant women regarding FT4 and TSH but not FT3 and antiTPO. Thyroid function abnormalities were increased with advance in pregnancy.

Conclusion: The discrepancy between FT4 and TSH in pregnancy is mostly due to presence of many stimulatory and inhibitory factors. Screening of FT4, TSH, HCG and TPO is important during pregnancy.