Endocrine Abstracts

Background: Low bone mineral density (BMD) and osteoporosis are the frequent consequences of Turner Syndrome (TS).

Objective and hypotheses: We examined the BMD in TS girls with different age and karyotype.

Methods: Measurements of BMD (g/cm²), Z-score (S.D.) were conducted in 26 girls using X-ray absorptiometry (DEXA) at the lumbar spine L2–L4 depending on the child’s age.

Results: According to the National registry of TS in Ukraine there are 453 girls with TS, aged 11 months-18.2 years. The prevalence is 77.5 per 100 000 live female new-borns or 0.06 per 1000 child population 0–18 year. Normal BMD (Z-score (−) 0.26±0.75 S.D.) had 23.13% patients, osteopenia (Z-score (−) 1.73±0.43 S.D.) − 46.21% and osteoporosis (Z-score (−) 2.86±0.41 S.D.) − 30.66% of girls. The smallest age, at which we recorded osteopenia was 9.3 year.

In patients with TS were determined statistically significant inverse correlation between age and Z-score (r=(−) 0.46, P<0.05), as well as between the level of FSH and Z-score (r=(−) 0.81, P<0.05).

Conclusion: Karyotype has not impact on BMD, osteopenia is present in all girls with different variants of karyotype. In girls with TS the degree of bone metabolism disorders progresses with age and degree of estrogen deficiency.