Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 EP173 | DOI: 10.1530/endoabs.41.EP173

ECE2016 Eposter Presentations Calcium and Vitamin D metabolism (61 abstracts)

Evaluation of renin-angiotensin-aldosterone system in patients with asymptomatic primary hyperparathyroidism

Emre Arslan , Alev Eroglu Altinova , Banu Aktas Yilmaz , Mujde Akturk , Ilhan Yetkin , Metin Arslan & Fusun Toruner

Gazi University Faculty of Medicine, Endocrinology and Metabolism Diseases Department, Ankara, Turkey.

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.

Methods: Thirty-two patients with asymptomatic PHPT and 22 healthy control subjects were recruited for this study. The levels of renin, aldosterone, PTH, calcium, phosphorus and 25-OH vitamin D were investigated.

Results: Median PTH and calcium levels were significantly higher in the patients with asymptomatic PHPT than the control group (155.0 (77.60) pg/ml vs 54.0 (13.20) pg/ml and 10.80 (0.45) vs 9.48 (0.56) mg/dl, P<0.05, respectively)). Median creatinine clearance levels were similar (100 ml/min (22.80) vs 102 ml/min (19.73), P>0.05, respectively). There was no statistically significant difference between plasma renin levels and plasma aldosterone concentrations (5.98 (7.35) vs 5.02 (12.87) and 95.14 (88.77) vs 105.92 (55.17), P>0.05, respectively). There were no correlations between calcium and PTH levels and renin or aldosterone levels (P>0.05).

Conclusion: Our results suggest no major alterations occur in the renin-angiotensin-aldosterone system in patients with asymptomatic PHPT.

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