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Endocrine Abstracts (2016) 41 EP416 | DOI: 10.1530/endoabs.41.EP416

1University of Warmia and Mazury, Clinic of Endocrinology, Diabetology and Internal Medicine, Olsztyn, Poland; 2Provincial Hospital in Olsztyn, Emergency Department, Olsztyn, Poland; 3The Warmia and Mazury Branch of the National Health Fund in Olsztyn, Olsztyn, Poland.


Introduction: The aim of the study was to examine the risk factors associated with diabetic retinopathy (DR) in adult patients with DM1 and DM2.

Design: The study group consisted of adults patients with DM1 and DM2, diagnosed according to the WHO criteria. Risk factors for diabetic retinopathy were evaluated on the demographic data, medical history, clinical and biochemical parameters related to metabolic control of diabetes. We collected also ophthalmic anamnesis: ophthalmic examination and the presence of diabetic eye complications before inclusion to the study. Statistical analysis was performed using the statistical package STATISTICA 10 GB and econometric program GRETL 1.9.9 cvs.

Results: We examined 1209 patients, age 54.9 (15.79) years, 315 (26%) DM1, age 37.0 (13.55) years, duration of diabetes 11.0 (8.60) years, and 894 (74%) DM2, age 61.2 (11.13) years, duration of the diabetes 10.5 (8.09) years. Patients were treated by Diabetologists (39%) and GP (61%). 42% were inhabitants of large cities, 28% small and medium cities and 26% from rural areas. HbA1c was significantly higher in DM1 8.44 (2.02)% vs. DM2 7.84 (1.67)%. DM1 patients were characterized by hyperfiltration and albuminuria. In DM2 albuminuria and low GFR were observed. Model of the logistic regression indicated following risk factors for DR: duration of diabetes, HbA1c, albumin/creatinine ratio, GFR, smoking and model therapy of DM.

Conclusions: 1) We found differences in the risk factors associated with DR between DM1 and DM2. 2) Risk factors for DR in the DM1: duration of DM, HbA1c, G1 stage of diabetic nephropathy, smoking. 3) Risk factors for DR in DM2: duration of DM, HbA1c, G2 stage of diabetic nephropathy, smoking, late introduction of insulin therapy in the management of hyperglycemia.

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