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Endocrine Abstracts (2016) 41 EP447 | DOI: 10.1530/endoabs.41.EP447

1Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey; 2Department of Genetic Research, Diskapi Teaching and Research Hospital, Ankara, Turkey; 3Department of Internal Medicine, School of Medicine (Kastamonu), Hacettepe University, Ankara, Turkey.

Introduction: Common polymorphisms of the fat mass and obesity associated gene (FTO) is known to associate with increased obesity and diabetes mellitus type 2. This was the first study to investigate the association between the rs9939609 FTO gene polymorphism and gestational diabetes mellitus (GDM) in Turkish women.

Patients and methods: The case-control study included 203 gestational diabetes and 191 non-diabetic pregnant controls. Anthropometric and biochemical measurements were performed. Genotyping of FTO rs9939609 was studied.

Results: GDM had significantly higher age, gestational weeks, body mass index, fasting blood glucose, fasting insulin, HOMA-IR, HbA1c, systolic and diastolic blood pressure; as compared to controls (P<0.05). The percentage of genotype TT (wild, 39.9 vs 41.1%), genotype AT (40.9 vs 46.6%) and genotype AA (19.2 vs 12%) were similar between GDM and controls, respectively. Genotype AA significantly had higher insulin and HOMA-IR than AT and TT. The FTO gene polymorphisms was not associated with an increased risk of GDM (P=0.05, OR=1.73, 95% CI 0.99–3.03).

Table 1 Clinical and biochemical parameters according to FTO genotype
Gestational age (wk)26.38±1.5325.95±1.5526.51±1.480.01
Body mass index (kg/m2)28.67±5.7727.16±4.4229.63±5.400.002
Fasting glucose (mg/dl)88.29±17.4685.96±17.5490.70±16.530.15
Fasting insulin (mIU/l)9.77±4.689.86±3.1512.22±4.900.001
HbA1c (%)5.29±0.465.23±0.435.31±0.510.13
Systolic blood pressure (mmHg)103.47±15.25107.06±12.92110.54±12.120.009
Diastolic blood pressure (mmHg)67.85±8.7169.07±7.1969.67±6.350.30

Conclusion: The FTO rs9939609 SNP was not associated with an increased risk of GDM in women with GDM. The further studies is needed to be conducted to examine whether these risk variants predict the development of GDM.

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