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Endocrine Abstracts (2016) 41 EP458 | DOI: 10.1530/endoabs.41.EP458

1Endocrinology Service UHC: Other Teresa, Tirana, Albania; 2Policlinic of Specialities Nr.2, Tirana, Albania; 3Imunology Service UHC Mother Teresa, Tirana, Albania; 4Statistic Department, Tirana, Albania; 5Neostyle Clinic, Tirana, Albania.

Background: Latent autoimmune diabetes of adults (LADA) constitutes 5–10% of the population with diabetes. Early diagnosis of LADA prevents misdiagnostification of type 2 diabetes and helps in the optimal treatment of patients, while maintaining a residual B cell function and delaying the time of their destruction.

Aim: The aim of the study identifying groups with higher risk of LADA in an Albanian population.

Material and methods: We recruited 149 neo-diagnosed diabetic patients aged from 30 to 60 years old. Age, sex, BMI, Waist circumference (WC), family history (FH), C-peptide, insulinaemia and anti-GAD antibodies were measured. Based on BMI the population was divided in three groups: (N) normal weight BMI <25 kg/m2, (Ov) overweight (BMI 25–30 kg/m2) and (Ob) obese BMI >30 kg/m2. According to family history the population was divided in positive FH and negative FH. LADA prevalence was calculated in all the groups.

Results: The overall LADA prevalence was 18.7%. The Prevalence of LADA in the N group was 33.3%, in the Ov group 30.9% and in the Ob group 9.5%. LADA’s prevalence in the positive FH group was 17.2% and in the negative FH group 34.7%. In the non obese group (N+Ov) with negative FH LADA’s prevalence reached 35.9% and increases even more in the N with negative FH the reaching 46.2%.

Conclusion: The overall LADA prevalence was 18.7%. According to our data subjects with normal weigh and no family history of diabetes have a higher risk of LADA, this emphasis the importance to investigate the autoimmune pattern in order to have earlier diagnosis and optimal treatment.

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