Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age. Clinical and biochemical characteristics are similar to metabolic syndrome. Insulin resistance in patients with metabolic syndrome, is associated with serum uric acid levels. In our study, we aimed to investigate the relationship between serum uric acid levels and clinical and laboratory in PCOS patients.
Materials and Method: PCOS patients and 34 age and body mass index (BMI) matched control, a total of 206 cases attending at endocrinology outpatients clinic included in the study. Early follicular phase, blood samples were taken after 12-hour fasting. Basal serum hormone levels were measured by immunoassay.
Results: Uric acid levels was statistically significantly higher in PCOS than control group (4.25±1.07 PCOS control 3.7±0.79, P=0.048). Uric acid levels were positively correlated with BMI, total cholesterol, insulin, cycle time, Feriman Gallwey score and negatively correlated with HDL cholesterol levels. Uric acid levels were higher than 2 times in PCOS group independently age and BMI with multivariate logistic regression.
Conclusion: Uric acid levels in study group was significantly higher independent of age and BMI. Cardiovascular risk factors; LDL, insulin, triglycerides, BMI was positively correlated with uric acid in PCOS group. Clinical indicators; Feriman Gallwey score and cycle time was also positively correlated. Elevated uric acid levels in PCOS patients may be a risk factor for cardiovascular disease, may show negative results in the clinic.