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Endocrine Abstracts (2016) 41 EP716 | DOI: 10.1530/endoabs.41.EP716

1Deparment of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey; 2Department of Pharmaceutical Toxicology, Gulhane School of Medicine, Ankara, Turkey.

Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. The pathogenesis of increased cardio-metabolic risk in hypogonadal patients is not clear. Oxidative stress plays an important role in the pathogenesis of cardio-metabolic diseases. The aim of this study was to search for any difference of the oxidative stress parameters between in patients with hypogonadism and healthy controls.

Materials and Methods: Thirty eight male patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age 21.7±1.6 years) and 44 body mass index (BMI) matched healthy male subjects (mean age 22.3±1.4 years) were enrolled. The demographic parameters, homeostatic model assessment of insulin resistance (HOMA-IR) and oxidative stress parameters such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and malondialdehyde (MDA) were measured in patients and healthy controls.

Results: When compared to the healthy controls, triglycerides (p=0.02), insulin, HOMA-IR, catalase and MDA levels (P=<0.001 for all) were significantly higher, and the HDL cholesterol (P=0.04), total testosterone, FSH, LH and GPx levels (P=<0.001 for all) were significantly lower in patients with CHH. There were significant correlations between the total testosterone levels and catalase (r=−0.33 P=0.01), GPx (r=0.36 P=0.007) and MDA (r=−0.47 P<0.001) levels.

Conclusions: The results of this study show that young and treatment naïve patients with hypogonadism have increased oxidative stress related parameters such as serum catalase and MDA levels. There is significant correlation between oxidative stress parameters and testosterone levels. Prospective, randomized, controlled studies with larger number of cases are needed to prove the relationship between oxidative stress and increased cardio-metabolic risk in hypogonadism.

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