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Endocrine Abstracts (2016) 41 EP973 | DOI: 10.1530/endoabs.41.EP973

1Endocrine Unit, Dept Med Therapeutics Alexandra Hospital, Athens University School of Medicine, Athens, Greece; 2Dept of Endocrinology, Metabolism and Diabetes, Athens University School of Medicine, Athens, Greece.

Introduction: Polymorphisms of the receptor for advanced glycation end products (AGEs), RAGE, have been associated with autoimmune disorders and their complications. There are no studies concerning Hashimoto’s thyroiditis (HT); the aim of our study was to investigate the possible role of two RAGE polymorphisms (−429T>C, −374T>A) in combination with indices of oxidative status in women with HT.

Design: We examined 300 euthyroid women (44.8±13yrs); 205 had HT (positive thyroid antibodies (ThAb(+)) and were separated in two groups; 96 under T4 replacement, 109 without. 95 women without ThAb and negative family history for HT were also studied (control). To evaluate oxidative stress, we measured total lipid peroxide levels in serum (TOS). Thyroid function tests were also performed. Genomic DNA was analyzed for the RAGE polymorphisms −429T>C AluI and −374T>A MfeI.

Results: Women with HT on T4 had higher TOS levels compared to those without treatment and to controls (mean TOS: 520 μmol/l vs 421.04 μmol/l vs 447.6 μmol/l, respectively, P=0.026). The prevalence of −429T>C RAGE polymorphism was significantly higher in this group compared to HT without treatment and controls (18.8% vs 11.9% vs 6.3% respectively, P=0.032). In the entire cohort, increased TOS and carrying the -429T>C polymorphism were independent predictors of HT (OR1.64, OR1.60 respectively. The coexistence of these factors had an additive effect (OR 5.4). The prevalence of −429T>C polymorphism was higher in women with DM2 compared to those without (33.3% vs 10.9%, P=0.009). There was no difference in the prevalence of −374T>A polymorphism r between the studied groups.

Conclusions: Women with increased TOS levels who are also carriers of the -429T>C polymorphism of RAGE are at increased risk to have Hashimoto’s thyroiditis and receive T4 replacement. These findings possibly suggest a role of this system in the elevated oxidative stress accompanying autoimmune thyroiditis.

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