Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 GP182 | DOI: 10.1530/endoabs.41.GP182

1Division of Endocrinology and Metabolism, Department of Internal Medicine (PCOS Research Group), Bozyaka Training and Research Hospital, Izmir, Turkey; 2Department of Obstetrics and Gynecology (PCOS Research Group), Manisa Merkezefendi State Hospital, Manisa, Turkey; 3Department of Biochemistry and Clinical Biochemistry, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey; 4Department of Bioengineering, Ege University, Izmir, Turkey; 5Department of Biotechnology, Ege University, Izmir, Turkey.

Context: Betatrophin is a newly identified hormone appreciated for its role as a potent inducer of beta cell proliferation in line with insulin resistance in mice. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance. However, no evidence was available whether betatrophin is involved in women with PCOS.

Objective: To ascertain whether betatrophin levels are altered in women with PCOS.

Setting: Secondary referral center.

Participants: A total of 164 women with PCOS and 164 age- and BMI- matched female controls without PCOS were recruited for this cross-sectional study.

Main outcome measures: Circulating betatrophin levels were measured using ELISA; metabolic and hormonal parameters were also determined.

Results: Circulating betatrophin levels were significantly elevated in women with PCOS compared with controls (367.09±55.78 vs 295.65±48.97 pg/ml, P<0.001). Betatrophin levels were positively correlated with insulin resistance marker HOMA-IR, free-testosterone, hs-CRP, atherogenic lipid profiles and BMI in PCOS. In multivariate logistic regression analysis, the odds of subjects in the highest quartile (OR=2.51, 95% CI=1.31–4.81, P=0.006) of betatrophin having PCOS were significantly increased compared with subjects the lowest quartile betatrophin. Multivariate regression analyses showed that HOMA-IR, hs-CRP and free-testosterone were independent factors influencing serum betatrophin levels.

Conclusion: Betatrophin levels were increased in women with PCOS and were associated with insulin resistance, hs-CRP and free-testosterone in these patients. Elevated betatrophin levels were found to increase the odds of having PCOS. The physiologic and pathologic significance of our findings remain to be further elucidated.

Article tools

My recent searches

No recent searches.