Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2016

Brighton, UK
07 Nov 2016 - 09 Nov 2016

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07 Nov 2016 to 09 Nov 2016 Brighton, UK Further information

Clinical Management Workshops

Workshop 2: Adrenal insufficiency and CAH

ea0044cmw2.1 | Workshop 2: Adrenal insufficiency and CAH | SFEBES2016

Dynamic control of tissue glucocorticoids and its implications for replacement therapy

Walker Brian

Although Endocrinologists have focused for decades on circulating concentrations of cortisol, arguably the important concentrations are those within tissues which are available at corticosteroid receptors. Tissue concentrations are influenced by plasma proteins binding cortisol, by physicochemical characteristics of the steroid, by active transport across cell membranes, and by steroid metabolism within target tissues. Many of these factors vary between individuals, and within...

ea0044cmw2.3 | Workshop 2: Adrenal insufficiency and CAH | SFEBES2016

Outcome in CAH around the globe

Debono Miguel

The management of congenital adrenal hyperplasia is challenging. Patients suffer from multiple morbidities related to excess androgens or glucocorticoid over-replacement. Multiple studies in Europe and the US have shown a high rate of metabolic complications in patients suffering from CAH including obesity, hypercholesterolaemia, insulin resistance, high blood pressure and low bone mineral density. Some studies have shown that patients with CAH have a poor quality of life and ...