Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 44 | SFEBES2016 | Next issue

Society for Endocrinology BES 2016

Brighton, UK
07 Nov 2016 - 09 Nov 2016

Card image cap
07 Nov 2016 to 09 Nov 2016 Brighton, UK Further information

Oral Communications

Adrenal and Steroids

ea0044oc4.1 | Adrenal and Steroids | SFEBES2016

Novel brain biomarkers of cognitive abnormalities identified in patients with congenital adrenal hyperplasia

Webb Emma A , Elliott Lucy , Carlin Dominic , Hall Kirsty , Barrett Timothy , Salwani Vijay , Arlt Wiebke , Krone Nils , Peet Andrew , Wood Amanda

Background: Management of patients with CAH remains challenging. There is increasing evidence to suggest that failure to optimize treatment during childhood not only affects final height but also leads to psychological and psychiatric problems. Previous qualitative structural T2-weighted MRI studies have identified white matter hyper-intensities in up to 46% of CAH patients. The nature and functional relevance of these abnormalities remains unknown.Objec...

ea0044oc4.2 | Adrenal and Steroids | SFEBES2016

Nicotinamide riboside and cellular NAD+ redox state influence 11β-HSD1 mediated glucocorticoid regeneration in skeletal muscle cells

Elhassan Yasir , Fletcher Rachel , Oldacre-Bartley Lucy , Doig Craig , Lavery Gareth

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is an NADPH-dependant oxo-reductase located in the sarcoplasmic reticulum (SR) lumen of skeletal muscle. Here it generates active glucocorticoids to regulate permissive and adaptive metabolism, and can mediate the pathological effects of glucocorticoid excess. Hexose-6-phosphate dehydrogenase (H6PD) in the SR interacts with 11β-HSD1 to generate an appropriate NADPH/NADP+ ratio to support activity. H6PD depletion...

ea0044oc4.3 | Adrenal and Steroids | SFEBES2016

Genome wide ChIP-Seq analysis of Glucocorticoid Receptor and RNA Polymerase 2 binding in rat liver during physiological and non-physiological corticosterone replacement

Flynn Benjamin P. , Birnie Matthew T. , Kershaw Yvonne M. , Baek Songjoon , Kim Sohyoung , Stavreva Diana A. , Hager Gordon L. , Lightman Stafford L. , Conway-Campbell Becky L.

Ultradian glucocorticoid (GC) secretion is highly conserved, having been detected in all species studied. The GC corticosterone (CORT) is a ligand for the glucocorticoid receptor (GR), inducing GR recruitment to glucocorticoid responsive elements (GREs) to modulate transcription of GC-target genes. We have previously demonstrated that pulsatile GR recruitment to GREs upstream of the Period1 gene is associated with its pulsatile transcription in rat liver. Similarly th...

ea0044oc4.4 | Adrenal and Steroids | SFEBES2016

A Single Nucleotide Polymorphism in the BACH2 Gene Contributes to Susceptibility to Autoimmune Addison’s Disease in UK and Norwegian cohorts

Pazderska Agnieszka , Oftedal Bergithe , Napier Catherine , Ainsworth Holly , Husebye Eystein , Cordell Heather , Pearce Simon , Mitchell Anna

Background: Autoimmune Addison disease (AAD) is a rare but highly heritable endocrinopathy. The BACH2 protein plays a crucial role in T lymphocyte maturation, and in particular in regulatory T cell formation, and allelic variation in its gene has been associated with autoimmune conditions such as type 1 diabetes, autoimmune thyroid disease and vitiligo. Its role in susceptibility to autoimmune Addison’s disease (AAD) has not been investigated.Aim: T...

ea0044oc4.5 | Adrenal and Steroids | SFEBES2016

ARID1a is required for regulation of a subset of glucocorticoid target genes involved in cell-cycle and p53 pathway regulation

Stubbs Felicity E. , Birnie Matthew T. , Fang Hai , Biddie Simon C. , Lightman Stafford L. , Conway-Campbell Becky L.

Clinically, glucocorticoids are widely used as a treatment mainly due to their potent anti-inflammatory abilities, however these are associated with several side effects and furthermore some patients go on to develop glucocorticoid resistance. ARID1a mutations have been linked to glucocorticoid resistance and are frequently identified across numerous cancers; therefore it is important to determine the functional role of ARID1a to GR signalling. The ATPase driven SWItch/Sucrose...

ea0044oc4.6 | Adrenal and Steroids | SFEBES2016

Demographics of adrenal incidentaloma – results from an international prospective multi-centre study in 2190 patients

Bancos Irina , Chortis Vasileios , Lang Katharina , Terzolo Massimo , Fassnacht Martin , Quinkler Marcus , Kastelan Darko , Vassiliadi Dimitra , Beuschlein Felix , Ambroziak Urszula , Deeks Jonathan , Arlt Wiebke

Background: Adrenal masses are discovered in 5% of cross-sectional abdominal imaging scans. Work-up aims at exclusion of malignancy and hormone excess. However, estimates of these risks presently derive from retrospective studies only, mostly small and with significant selection bias.Methods: Prospective multi-centre study (2011–2016) in 21 centres (17 countries) of the European Network for the Study of Adrenal Tumours (ENSAT) with consecutive enrol...