Endocrine Abstracts

Inpatient hypoglycaemia is common and associated with adverse outcome during admission and post discharge. We investigated management of hypoglycaemia using the time to repeat (TTR) capillary blood glucose (CBG) measurement as a surrogate for engagement with clinical guidelines.Methods: Inpatient CBG data from 8 hospitals over a 7 y period were analysed. Primary care prescribing information was available, and admissions were associated with insulin or SU...

The incretin hormone glucagon-like peptide-1 (GLP-1) has been proposed to increase beta cell mass, via effects on proliferation, apoptosis and neogenesis. However, the role of GLP-1 during normal human development is unclear. We have addressed this in human fetuses by quantifying GLP-1 secretion during fetal development and determining how GLP-1 signalling impacts on early human fetal pancreas in explant culture.GLP-1 is first secreted by the stomach, du...

The identification and characterisation of unique gene profiles expressed in specific adipose tissue depots around the body could provide novel insights on fat development.We report a comprehensive analysis of transcriptome from the five major (epicardial, pericardial, perirenal, sternal and omental) adipose depots from one week old sheep. This study also provides an integrated view of the preservation and differences between mitochondrial gene co-expres...

IAS is a very rare condition in which anti-insulin antibodies carry high concentrations of insulin in suspension in circulation. Hypoglycaemia occurs when insulin is released from the antibodies during fasting or post-prandially.We present two cases. Patient-A is a 52-year old Thai obese female, with acanthosis nigricans and a strong family history of T2DM. Patient-B is a 28 year-old normal- BMI Caucasian female with an unremarkable history. None of the ...

Non-alcoholic fatty liver disease is the hepatic manifestation of metabolic disease. 5β-reductase (AKR1D1) is highly expressed in human and rodent liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis. Steroid hormones, including glucocorticoids, as well as bile acids are established regulators of metabolic phenotype. We have hypothesized that AKR1D1 plays a crucial regulatory role in hepatic metabolic homeostasis.<p class...

Genome-wide association studies have repeatedly shown that the strongest association with human BMI is arising from variants in the first intron of Fto. It has recently been demonstrated that intronic Fto variants are within an adipocyte-specific enhancer and that risk allele carriers have altered Irx3 and Irx5 expression in early adipogenesis (Claussnitzer et al. NEJM 2015). The aim of our study is to investigate the functional role of Irx3 in adipocytes. We show that silenci...