Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2016

Brighton, UK
07 Nov 2016 - 09 Nov 2016

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07 Nov 2016 to 09 Nov 2016 Brighton, UK Further information

Plenary Lectures

Clinical Endocrinology Trust Visiting Professor Lecture

ea0044pl9 | Clinical Endocrinology Trust Visiting Professor Lecture | SFEBES2016

Genomics and Steroidobolomics in Cushing's syndrome: the perspective of a clinician scientist

Reincke Martin

Cushing's disease results from uncontrolled ACTH secretion by corticotroph adenomas of the pituitary, resulting in excess cortisol secretion. Numerous previous studies attempted to gain insight into the molecular mechanisms underlying the development of Cushing’s disease, but only few rare mutations have been reported. Recently, an exhaustive exome-wide screening has led us to identify somatic mutations in the ubiquitin-specific protease 8 (USP8) in 36% of adenomas...