Endocrine Abstracts

Approximately 20% of women with Turner syndrome (TS) proceed normally through puberty with spontaneous menstruation. An increasing number of women with TS are taking advantage of oocyte cryopreservation which is becoming widely available. It may be expected however, that controlled ovarian stimulation would result in fewer than expected number of oocytes compared to women without TS. We report our initial results from women with TS undergoing this procedure.

Five women with TS requested oocyte cryopreservation. Clinical details and outcome of ovarian stimulation are shown in the table.

Results: The majority (4/5) all women had a mosaic form of TS. Despite relatively low serum AMH concentrations, oocyte retrieval was successful in all attempts with an average of 9 oocytes.

Conclusion: Oocyte cryopreservation is an option for women with Turner syndrome who have preserved ovarian function with oocyte retrieval very similar to published data from women without TS. The outcome in terms of live birth rate is yet to be determined and will be adversely affected by additional procedures such as preimplantation genetic diagnosis in order to minimise the chance of chromosomal anomalies in offspring.