Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Reproductive Endocrinology

Endocrine tumours and neoplasia

ea0049ep1093 | Endocrine tumours and neoplasia | ECE2017

Molecular mechanisms underlying progesterone-enhanced breast cancer cell proliferation

Wang Hui-Chen

Previously, we demonstrated that progesterone (P4) could enhance breast cancer cell migration through increasing formation of the p27-RhoA complex and RhoA activation caused by the cSrc/AKT-mediated phosphorylation of p27 at T198. Here, we further examined the effect of P4 on breast cancer cell proliferation. Our results show that P4 (12.5–100 nM) concentration-dependently enhanced proliferation in breast cancer cell lines (T47D and MCF-7). We also found that increases of...

ea0049ep1094 | Endocrine tumours and neoplasia | ECE2017

Study of CYP17 and PSA G158A polymorphisms in prostate cancer

Vladoiu Suzana , Manda Dana , Oros Sabina , Schipor Sorina , Preda Adrian , Gener Ismail , Picu Catalina , Rosca Roxana , Badiu Corin

The relationship between the level of genetic variation in CYP17, PSA genes and prostate cancer has been extensively studied but the results are still unclear. A 450c17a (CYP17) polymorphism A1/A2 was described to be significantly associated to prostate cancer. A SNP in the promotor PSA gene is an A to G substitution at position −158 (G158A) was proposed to interact differently with AR, thereby modifying the expression pattern and occurrence of prostate cancer.<p cla...