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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Bone & Calcium Homeostasis 1

ea0049gp33 | Bone & Calcium Homeostasis 1 | ECE2017

“Hyperparanet”: a multicenter Italian study on Primary Hyperparathyroidism

Saponaro Federica , Cetani Filomena , Camozzi Valentina , D'Angelo Antonella , Minisola Salvatore , Scillitani Alfredo , Cipri Claudia , Palmieri Serena , Chiodini Iacopo , Romanelli Francesco , Madeo Bruno , Castellano Elena , Gianotti Laura , Faggiano Antongiulio , Cianferotti Luisella , Brandi Maria Luisa , Corbetta Sabrina , De Feo Maria Laura , Palermo Andrea , Marcocci Claudio

The aim of the present study was to evaluate the phenotype of PHPT, the adherence to International Guidelines and the rate of surgical cure of PHPT in Italy. From January 2014–January 2016, we conducted a prospective, multicenter (n=29 endocrine tertiary referral centers) study on patients with PHPT, recording clinical and biochemical data, parathyroid imaging and therapy choice at baseline and at last follow-up. The study group included 604 patients with PHPT, w...

ea0049gp34 | Bone & Calcium Homeostasis 1 | ECE2017

Fat mass distribution and resistin are independent predictors of bone mass in postmenopausal, but not premenopausal women.

Bilha Stefana Catalina , Ungureanu Maria-Christina , Cianga Petru , Buzduga Catalin , Aancute Adrian , Zaharia Valentin , Constantinescu Daniela , Anisie Ecaterina , Covic Adrian , Branisteanu Dumitru

Introduction: Body weight and lean mass (LM) are classic bone mass determinants. However, the association between total fat mass (FM), regional FM and bone remains controversial, especially as fat is a source of adipocytokines, with both positive and negative bone consequences.Materials and methods: Anthropometric, bone mass (assessed by Dual X-Ray Absorptiometry; DXA) and body composition parameters (assessed by DXA) and also serum adipocytokine (leptin...

ea0049gp35 | Bone & Calcium Homeostasis 1 | ECE2017

Aldosterone and parathyroid hormone – is there a connection?

Ventura Mara , Melo Miguel , Oliveira Diana , Martins Diana , Lages Adriana , Cunha Nelson , Carrilho Francisco

Introduction: Recent studies seem to support a bidirectional positive interaction between aldosterone and parathyroid hormone (PTH). Understanding the normal physiological relationship between renin-angiotensin-aldosterone system (RAAS) and PTH is of clinical interest because their inappropriate activity may negatively impact cardiovascular and skeletal health.Objective: To evaluate the presence of an interaction between aldosterone and PTH in a cohort o...

ea0049gp36 | Bone & Calcium Homeostasis 1 | ECE2017

Relationship between circulating microRNAs and bone mineral density in patients with active acromegaly

Valassi Elena , Garcia-Giralt Natalia , Malouf Jorge , Crespo Iris , Webb Susan M.

Objective: Acromegaly (ACRO) is associated with abnormal bone remodeling and reduced volumetric bone mineral density (vBMD) at the lumbar spine and proximal femur. Circulating microRNAs (miRNAs) modulate the activity of osteoblasts and osteoclasts, and are currently being investigated as potential biomarkers of osteoporosis. The aims of our study were: 1) To identify differentially expressed miRNAs in the serum of five patients with active ACRO vs. healthy controls, and 2) To ...

ea0049gp37 | Bone & Calcium Homeostasis 1 | ECE2017

Effects of BCR-ABL targeted tyrosine kinase inhibitors on the whole transcriptome pattern of cultured murine osteoblasts

Balla Bernadett , Kirschner Gyongyi , Horvath Peter , Lakatos Gergely , Kosa Janos , Lakatos Peter

Breakpoint cluster region abelson fusion oncoprotein (BCR-ABL) targeted tyrosine kinase inhibitors (TKIs) are widely used in long-term medications of hematological malignancies. Numerous clinical observations confirmed that these drugs significantly modify the physiology of bone tissue as a side effect. Currently, there are numerous contradictory results regarding the complex effects of TKIs on bone metabolism, as well as there is no clear evidence to explain them, either in t...

ea0049gp38 | Bone & Calcium Homeostasis 1 | ECE2017

Decreased trabecular bone score but not bone mineral density in patients with acromegaly and concurrent hypogonadism: cross-sectional study with healthy controls

Kužma Martin , Pavai Dušan , Sagova Ivana , Killinger Zdenko , Jackuliak Peter , Vaňuga Anton , Vaňuga Peter , Payer Juraj

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.</p...

ea0049gp39 | Bone & Calcium Homeostasis 1 | ECE2017

Association of changes in serum urate level and bone mineral density during treatment with teriparatide: a retrospective observational study

Kocjan Tomaz , Vidmar Gaj , Rajic Antonela Sabati , Jensterle Sever Mojca , Pfeifer Marija , Marc Janja , Orehek Nina , Ostanek Barbara

Serum urate level has recently been associated with increased bone mineral density (BMD). Teriparatide, an osteoanabolic medication for osteoporosis, is associated with increased incidence of hyperuricemia. Hence, we hypothesized that changes in serum urate are associated with changes in BMD and procollagen type 1 N-terminal propeptide (P1NP) during treatment with teriparatide.We collected data from 151 women (mean age 72 years, mean BMI 26.6 kg/m2<...

ea0049gp40 | Bone & Calcium Homeostasis 1 | ECE2017

Coexistence of primary hyperparathyroidism with papillary thyroid carcinoma: a case series

Anagnostis Panagiotis , Panagiotou Athanasios , Adamidou Fotini , Rafailidis Savvas , Kita Marina

Introduction: Primary hyperparathyroidism (PHPT) may rarely coexist with non-medullary thyroid carcinoma (NMTC). We report the clinical manifestation and management of nine cases of synchronous PH and NMTC.Cases: Eight women and one man were included (mean age at diagnosis: 64±6.6 years). In all cases, PH was the initial diagnosis, whereas NMTC was detected incidentally, after ultrasound assessment for PH. The histological diagnosis of NMTC was clas...

ea0049gp41 | Bone & Calcium Homeostasis 1 | ECE2017

Follow-up of patients with surgical hypoparathyroidism: unknown cause of renal function decline?

van de Meerhaeghe Tess , Bukovski Sergei , Coudenys Elien , Unuane David , Velkeniers Brigitte , Bravenboer Bert

Background: Hypoparathyroidism is a rare endocrine disease with low calcium and insufficient parathyroid hormone levels. In most cases it is caused by thyroid surgery. The objective of this retrospective cohort study was to evaluate if the typical therapy regimens of postsurgical hypoparathyroidism with calcitriol have a negative effect on renal function. Methods: We performed a chart analysis of patients that were seen in a tertiary care hospital in Bru...

ea0049gp42 | Bone & Calcium Homeostasis 1 | ECE2017

Expression of hypoxia-inducible factor-1α in Calbindin-D9k Knockout mice

Kang Song Ai , Park Seon Young , An Jin Yong , Jeung Eui-Bae

Introduction: Hypoxia-inducible factors (HIF) are the key transcription factor induced by hypoxic condition, which regulate expression of specific target genes including angiogenic factors, erythropoietin, glucose transporters, and glycolytic enzymes. Recently, many studies connected to intracellular calcium levels and regulation of HIF-1α protein level. Calbindin-D9k is a cytosolic calcium-binding protein and compensate with other calcium transporter protein f...