Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 49 | ECE2017 | Next issue

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

Card image cap
20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Female Reproduction

ea0049gp131 | Female Reproduction | ECE2017

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial

Prague Julia , Roberts Rachel , Comninos Alexander , Clarke Sophie , Jayasena Channa , Nash Zachary , Doyle Chedie , Papadopoulou Deborah , Bloom Stephen , Mohideen Pharis , Panay Nicholas , Hunter Myra , Veldhuis Johannes , Webber Lorraine , Huson Les , Dhillo Waljit

Background: Hot flushes affect 70% of menopausal women, can be long-lasting, and often severely impact on physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is effective but not without risk. Neurokinin B is an important mediator of hot flushes in rodents and elevated hypothalamic expression occurs in menopausal women. Neurokinin B acts via the neurokinin 3 receptor. We therefore hypothesised that neurokinin 3 receptor antagonism could be a nove...

ea0049gp132 | Female Reproduction | ECE2017

Testosterone administration decreases insulin sensitivity (IS) in adult female sheep born to testosterone treated mothers

Carrasco Albert , Recabarren Monica P , Sandoval Daniel , Sir-Petermann Teresa , Recabarren Sergio E

Different animal models have been used to study the postnatal effect of a prenatal exposure to an androgen excess on the female offspring. We have established a sheep model to test the hypothesis that the intrauterine environment of the PCOS mother may play a role in the etiology of the PCOS. In this regard, our sheep model for the study of PCOS has the advantage that provides mainly an androgenized milieu to the fetus in comparison to pregnant PCOS women who offers a hyperand...

ea0049gp133 | Female Reproduction | ECE2017

Influence of BMI on AMH levels in non-PCOS women

Simoes-Pereira Joana , Nunes Joaquim , Aguiar Ana , Sousa Sandra , Rodrigues Catia , Matias J Sampaio , Calhaz-Jorge Carlos

Introduction: Anti-Müllerian Hormone (AMH) is a useful marker of ovarian reserve (OR), since it remains stable inter/intra-cycles and presents a good correlation with ultrasonographic antral follicular count. Obesity/overweight are increasing and may affect the reproductive health. However, previous studies regarding the effect of body mass index (BMI) on AMH levels are discordant. Our main goal was to evaluate the influence of BMI in AMH levels in women with infertility....

ea0049gp134 | Female Reproduction | ECE2017

Relugolix, an oral gonadotropin-releasing hormone (GnRH) receptor antagonist, in women with endometriosis (EM)-associated pain: Phase 2 safety and efficacy 24-week results

Osuga Yutaka , Seki Yoshifumi , Tanimoto Masataka , Kusumoto Takeru , Kudou Kentarou , Terakawa Naoki

Objective: The objective of this Phase 2 study was to evaluate the safety of relugolix when administered for 24 weeks in women with EM-associated pain. Efficacy was exploratory assessed using leuprorelin as a reference.Design: This was an open-label extension study evaluating safety of 3 doses (10 mg, 20 mg, and 40 mg) of relugolix administered orally once daily for a total of 24 weeks in women with EM-associated pain, who had participated in a preceding...

ea0049gp135 | Female Reproduction | ECE2017

Brown adipose tissue thermogenesis in women with polycystic ovary syndrome

Shorakae Soulmaz , Jona Eveline , de Courten Barbora , Lambert Gavin , Lambert Elisabeth , Phillips Sarah , Clarke Iain , Teede Helena , Henry Belinda

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive age women and is characterized by reproductive, metabolic and psychological features exacerbated by weight gain. Weight management in PCOS is challenged by propensity to weight gain and lack of sustainable dietary interventions. Body weight is regulated by calorie intake and the rate of energy expenditure. Metabolically active brown adipose tissue (BAT), contributing to energy dissipation, has b...

ea0049gp136 | Female Reproduction | ECE2017

Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin improved beta cell function and prevented a conversion rate to MTG and DM2 in metformin intolerant PCOS with high metabolic risk

Janez Andrej , Ferjan Simona , Jensterle Mojca

Objective: Metformin is the first-line therapy for PCOS with high metabolic risk, yet a large proportion of patients cannot tolerate it due to associated gastrointestinal adverse events. The alternative pharmacological strategy when metformin cannot be tolerated is not well established in this population. Our aim was to evaluate whether sitagliptin (SITA) preserves metabolic profile in metformin (MET) intolerant PCOS with high metabolic risk.Design and m...

ea0049gp137 | Female Reproduction | ECE2017

Genetic susceptibility for adrenal hyperandrogenism in polycystic ovary syndrome

Baculescu Nicoleta , Haydar Sarah , Gheorghiu Monica Livia , Radian Serban , Lautier Corinne , Poiana Catalina , Pugeat Michel , Grigorescu Florin

Background: Hyperandrogenism is a main feature of the polycystic ovary syndrome (PCOS). Although its ovarian origin is well recognized, laboratory investigation suggested the contribution of adrenal gland, albeit of unknown mechanism.Aim: To understand the contribution of genetic factors in adrenal hyperandrogenism (AH) we investigated genome wide SNPs in subgroups of PCOS patients stratified as function of DHEAS levels in two ethnic populations (Romania...

ea0049gp138 | Female Reproduction | ECE2017

Turner’s syndrome and abnormal liver chemistry: relationship with karyotype in a large dedicated clinic

Calanchini Matilde , Moolla Ahmad , Tomlinson Jeremy W , Cobbold Jeremy , Fabbri Andrea , Grossman Ashley , Turner Helen

Introduction: Abnormal liver function tests (↑LFTs) are frequently observed in Turner’s syndrome (TS), although the aetiology is unclear. Obesity is reported as one of the causes; recently an increased prevalence of elevated GGT was found in TS patients with a ring X karyotype.Aim: To analyse the association between abnormal LFTs and TS-related conditions, and in particular their relationship with the different TS-karyotypes.<p class="abst...

ea0049gp139 | Female Reproduction | ECE2017

Sensitivity of hypothalamo-pituitary-adrenal axis in women with PCOS

Macut Djuro , Bozic-Antic Ivana , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Bogavac Tamara , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja

Introduction: Increased adrenal androgen production is present in 20–60% of women with polycistic ovary syndrome (PCOS). Possible mechanism is not clarified yet and could be related to altered hypothalamic-pituitary-adrenal-axis (HPA) activity or a consequence of adrencortical steroidogenic abnormalities. The aim of the study was to assess HPA sensitivity in PCOS women using different doses of dexamethasone.Methods: We analyzed 359 women with PCOS d...

ea0049gp140 | Female Reproduction | ECE2017

Nonalcoholic fatty liver disease liver fat score (NAFLD-LFS) could be used for the assessment of NAFLD in women with PCOS

Bjekic-Macut Jelica , Bozic-Antic Ivana , Tziomalos Konstantinos , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Macut Djuro

Introduction: A relation between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) was demonstrated recently. Both NAFLD and PCOS are associated with increased risk for type 2 diabetes and cardiovascular disease. NAFLD liver fat score (NAFLD-LFS) has been implicated as a non-invasive surrogate marker for NAFLD. The aim of this study was to identify the prevalence of NAFLD in different PCOS phenotypes using NAFLD-LFS.Methods: W...

ea0049gp141 | Female Reproduction | ECE2017

Effects of central sympathoinhibition with moxonidine on the elevated sympathetic nervous activity and downstream metabolic abnormalities observed in polycystic ovary syndrome

Shorakae Soulmaz , Lambert Elisabeth , Jona Eveline , Sari Carolina Ika , de Courten Barbora , Lambert Gavin , Teede Helena

The role of the sympathetic nervous system (SNS) in the pathophysiology of PCOS and associated cardiometabolic risks is emerging. Previous studies support increased SNS activity in PCOS, potentially contributing to metabolic features via multiple mechanisms including insulin resistance. Moxonidine is a second-generation imidazoline I1 agonist, acting centrally, inhibiting sympathetic outflow at the level of rostral ventrolateral medulla with known beneficial effects...

ea0049gp142 | Female Reproduction | ECE2017

Steroid receptors involvement in enamel hypomineralization resulting from exposure to low-dose DEHP and bisphenol A

Ai Thu Bui , Houari Sophia , Loiodice Sophia , Jedeon Katia , Berdal Ariane , Babajko Sylvie

The environment has become increasingly contaminated by various pollutants including endocrine disrupting chemicals (EDCs). This has led to an increase in the incidence and gravity of known pathologies and the emergence of new ones, including dental pathologies as the Molar Incisor Hypomineralization (MIH). Among the thousands of EDCs, bisphenol A (BPA) and phthalates (DEHP) are widely used by the plastic industry and responsible to frequent contaminations. We previously showe...